Results 91 to 100 of about 492 (130)

ChemInform Abstract: APORPHINES. 31. SYNTHESIS AND ANTITUMOR ACTIVITY OF APORPHINE NITROGEN MUSTARDS

Chemischer Informationsdienst, 1981
AbstractDargestellt werden die Verbindungen (I), die Antitumor‐Wirkung besitzen.
J. L. NEUMEYER, F. E. GRANCHELLI, C. N. FILER, A. H. SOLOWAY, S.‐J. LAW   +4 more
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Topoisomerase II inhibition by aporphine alkaloids

Biochemical Pharmacology, 1999
The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding assay.
S H, Woo, N J, Sun, J M, Cassady, R M, Snapka   +3 more
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Antitumor aporphine alkaloids from Thalictrum wangii

Fitoterapia, 2018
Nine new isoquinoline alkaloids, including two proaporphine (1-2), three aporphine (3-5), two oxoaporphine (6-7), and two seco-bisbenzylisoquinoline (8-9), together with three known alkaloids (10-12) were isolated from the whole plant of Thalictrum wangii. Their structures were established on the basis of spectroscopic data. The antitumor activities of
Qiong, Jin, Dong, Yang, Zhi, Dai, Afsar, Khan, Bei, Wang, Xin, Wei, Ying, Sun, Yun-Li, Zhao, Yi-Fen, Wang, Ya-Ping, Liu, Xu-Dong, Zhao, Xiao-Dong, Luo   +11 more
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ChemInform Abstract: APORPHINES. 23. NORMORPHOTHEBAINE DERIVATIVES‐ SYNTHESIS OF AN APORPHINE NITROGEN MUSTARD

Chemischer Informationsdienst, 1977
AbstractAus den Morphinen (Ia) und (Ib) entstehen mit HCl die Umlagerungsprodukte (IIa) und (IIb).
F. E. GRANCHELLI, A. N. SOLOWAY, J. L. NEUMEYER, C. N. FILER   +3 more
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Preparation and pharmacological evaluation of enantiomers of certain nonoxygenated aporphines: (+)- and (-)-aporphine and (+)- and (-)-10-methylaporphine

Journal of Medicinal Chemistry, 1993
The subject compounds were prepared as a part of a continuing structure-activity study of the contrasting actions (agonism-antagonism) of (+)- and (-)-11-hydroxy-10-methylaporphine at serotonin (5-HT1A) receptors. None of the targeted nonoxygenated aporphine derivatives demonstrated significant activity in assays for any effects at serotonin 5-HT1A ...
J G, Cannon, R, Raghupathi, S T, Moe, A K, Johnson, J P, Long   +4 more
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Aporphines: 25—Trimethylsilyl derivatives ofN-methyl andN-propyl aporphines: Gas chromatographic and mass spectrometric properties

Biological Mass Spectrometry, 1979
A series of synthetic, semisynthetic and naturally occurring aporphine alkaloids were converted to the O-trimethylsilyl derivatives, and analyzed by gas chromatography mass spectrometry. A discussion of structurally informative fragment ions along with gas chromatographic data is presented.
J F, Green, J V, Evans, J L, Neumeyer, P, Vouros   +3 more
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Dimeric Aporphine-Benzylisoquinoline and Aporphine-Pavine Alkaloids

Journal of Natural Products, 1979
Hélène, Guinaudeau, Michel, Leboeuf, André, Cavé   +2 more
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Aporphine and Morphinan Alkaloids

1968
The aporphine and morphinan alkaloids can be conveniently considered together because they often occur together in the same plant, and also because in terms of structure they can both be derived from a benzylisoquinoline skeleton by additional ring closures:
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Aporphine alkaloids

Chemistry of Natural Compounds, 1980
I. A. Israilov, S. U. Karimova, M. S. Yunusov, S. Yu. Yunusov   +3 more
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Photochemical synthesis of aporphines

The Journal of Organic Chemistry, 1971
S M, Kupchan, J L, Moniot, R M, Kanojia, J B, O'Brien   +3 more
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