Results 131 to 140 of about 2,909 (211)

Integrative open workflow for confident annotation and molecular networking of metabolomics MSE/DIA data. [PDF]

Brief Bioinform
Katchborian-Neto A, Alves MF, Bueno PCP, de Jesus Nicácio K, Ferreira MS, Oliveira TB, Barbosa H, Murgu M, de Paula Ladvocat ACC, Dias DF, Soares MG, Lago JHG, Chagas-Paula DA.   +12 more
europepmc   +1 more source

Boldo leaves reduce seizures, neuroinflammation, and hemichannel activity in a murine model of chronic epilepsy. [PDF]

Biol Res
García-Rodríguez C, Flores-Muñoz C, Fernández P, Escobar M, Ardiles ÁO, Cardenas AM, Sáez JC.   +6 more
europepmc   +1 more source

Synthesis, Antiacetylcholinesterase Activity, and Molecular Dynamics Simulation of Aporphine-benzylpyridinium Conjugates. [PDF]

ACS Med Chem Lett
Khunnawutmanotham N, Sooknual P, Batsomboon P, Ploypradith P, Chimnoi N, Patigo A, Saparpakorn P, Techasakul S.   +7 more
europepmc   +1 more source

Synthesis and stereochemistry of some isoquinoline alkaloids and related compounds. [PDF]

, 1978
Warren, Paul
core  

New, centrally acting dopaminergic agents with an improved oral bioavailability:synthesis and pharmacological evaluation [PDF]

, 2000
Rodenhuis, Nieske
core   +2 more sources

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Aporphines: A privileged scaffold in CNS drug discovery.

European journal of medicinal chemistry, 2023
Aporphine alkaloids embedded in 4H-dibenzo[de,g]quinoline four-ring structures belong to one of the largest subclasses of isoquinoline alkaloids. Aporphine is a privileged scaffold in the field of organic synthesis and medicinal chemistry for the ...
Rongfeng Zhu, G. Jiang, Wanyu Tang, Xiaobao Zhao, Fan Chen, X. Zhang, Na Ye   +6 more
semanticscholar   +1 more source

Photochemical synthesis of aporphines

The Journal of Organic Chemistry, 1971
S M, Kupchan, J L, Moniot, R M, Kanojia, J B, O'Brien   +3 more
openaire   +3 more sources

Aporphines and Alzheimer's disease: Towards a Medical Approach Facing the Future.

Current Medicinal Chemistry, 2019
Alzheimer's disease (AD) is a neurodegenerative disease that is reducing progressively the part cognitive inside the Central Nervous System (CNS) and that affects the memories and emotions of the patients who endure this disease.
S. Nabavi, E. Uriarte, L. Rastrelli, E. Sobarzo-Sánchez   +3 more
semanticscholar   +1 more source

Aporphines. 31. Synthesis and antitumor activity of aporphine nitrogen mustards

Journal of Medicinal Chemistry, 1980
A series of aporphine nitrogen mustards and their congeners (1b-g) has been prepared. N-[[Bis(2-chloroethyl)-amino]-2,11-dihyroxy-10-methoxynoraporphine (1b) and its mono- and diacetyl ester derivatives (1c-d) were prepared from N-(chloroacetyl)-2,11-diacetoxy-10-methoxynoraporphine (2).
J L, Neumeyer, F E, Granchelli, C N, Filer, A H, Soloway, S J, Law   +4 more
openaire   +2 more sources

New Analogues of Aporphine Alkaloids

Mini-Reviews in Medicinal Chemistry, 2018
Aporphine alkaloids, characterized by a heterocyclic aromatic basic skeleton, are known from different organisms and exhibit various biological activities: anti-tumor, anti-viral, anti-microbial, anti-inflammatory etc. The review gives information which provides an overview of the latest progress in the structural diversity and the biological activity ...
Yi-Chao, Ge, Kui-Wu, Wang
openaire   +2 more sources