Results 141 to 150 of about 2,909 (211)

New Cytotoxic Tetrahydroprotoberberine-Aporphine Dimeric and Aporphine Alkaloids fromCorydalis turtschaninovii

Planta Medica, 2010
Two new tetrahydroprotoberberine-aporphine dimeric alkaloids, corydaturtschines A (1) and B (2), and a new aporphine derivative, ethyl glausuccinate (3), together with 13 known protoberberine (4-16) and nine known aporphine alkaloids (17-25), were isolated from the tubers of Corydalis turtschaninovii.
Ki Hyun, Kim, Cheng Jie, Piao, Sang Un, Choi, Mi Won, Son, Kang Ro, Lee   +4 more
openaire   +2 more sources

Aporphines. 22. Electrochemical synthesis of aporphines via cathodic cyclization of iodobenzylisoquinolinium salts

Journal of the American Chemical Society, 1976
Elektrolyse der Isochino1inium- Salze (I) liefert die Cyclisierungsprodukte (II), aus denen durch katalytische Hydrierung die Aporphine (III) gewonnen werden [keine Isolierung von (IIb); keine Ausbeuteangabe fur (IIIb)].
R, Gottlieb, J L, Neumeyer
openaire   +2 more sources

Circular Dichroism of Aporphines

Journal of Natural Products, 1981
Bjorn Ringdahl, Rosalind P. K. Chan, J. Cymerman Craig, M. P. Cava, M. Shamma   +4 more
openaire   +2 more sources

ChemInform Abstract: APORPHINES. 31. SYNTHESIS AND ANTITUMOR ACTIVITY OF APORPHINE NITROGEN MUSTARDS

Chemischer Informationsdienst, 1981
AbstractDargestellt werden die Verbindungen (I), die Antitumor‐Wirkung besitzen.
J. L. NEUMEYER, F. E. GRANCHELLI, C. N. FILER, A. H. SOLOWAY, S.‐J. LAW   +4 more
openaire   +1 more source

Topoisomerase II inhibition by aporphine alkaloids

Biochemical Pharmacology, 1999
The aporphine alkaloids (+)-dicentrine and (+)-bulbocapnine are non-planar molecules lacking features normally associated with DNA binding by intercalation or minor groove binding. Surprisingly, dicentrine showed significant activity as a topoisomerase II (EC 5.99.1.3) inhibitor and also was active in a DNA unwinding assay.
S H, Woo, N J, Sun, J M, Cassady, R M, Snapka   +3 more
openaire   +2 more sources

Antitumor aporphine alkaloids from Thalictrum wangii

Fitoterapia, 2018
Nine new isoquinoline alkaloids, including two proaporphine (1-2), three aporphine (3-5), two oxoaporphine (6-7), and two seco-bisbenzylisoquinoline (8-9), together with three known alkaloids (10-12) were isolated from the whole plant of Thalictrum wangii. Their structures were established on the basis of spectroscopic data. The antitumor activities of
Qiong, Jin, Dong, Yang, Zhi, Dai, Afsar, Khan, Bei, Wang, Xin, Wei, Ying, Sun, Yun-Li, Zhao, Yi-Fen, Wang, Ya-Ping, Liu, Xu-Dong, Zhao, Xiao-Dong, Luo   +11 more
openaire   +2 more sources

ChemInform Abstract: APORPHINES. 23. NORMORPHOTHEBAINE DERIVATIVES‐ SYNTHESIS OF AN APORPHINE NITROGEN MUSTARD

Chemischer Informationsdienst, 1977
AbstractAus den Morphinen (Ia) und (Ib) entstehen mit HCl die Umlagerungsprodukte (IIa) und (IIb).
F. E. GRANCHELLI, A. N. SOLOWAY, J. L. NEUMEYER, C. N. FILER   +3 more
openaire   +1 more source

Preparation and pharmacological evaluation of enantiomers of certain nonoxygenated aporphines: (+)- and (-)-aporphine and (+)- and (-)-10-methylaporphine

Journal of Medicinal Chemistry, 1993
The subject compounds were prepared as a part of a continuing structure-activity study of the contrasting actions (agonism-antagonism) of (+)- and (-)-11-hydroxy-10-methylaporphine at serotonin (5-HT1A) receptors. None of the targeted nonoxygenated aporphine derivatives demonstrated significant activity in assays for any effects at serotonin 5-HT1A ...
J G, Cannon, R, Raghupathi, S T, Moe, A K, Johnson, J P, Long   +4 more
openaire   +2 more sources

Aporphines: 25—Trimethylsilyl derivatives ofN-methyl andN-propyl aporphines: Gas chromatographic and mass spectrometric properties

Biological Mass Spectrometry, 1979
A series of synthetic, semisynthetic and naturally occurring aporphine alkaloids were converted to the O-trimethylsilyl derivatives, and analyzed by gas chromatography mass spectrometry. A discussion of structurally informative fragment ions along with gas chromatographic data is presented.
J F, Green, J V, Evans, J L, Neumeyer, P, Vouros   +3 more
openaire   +2 more sources

Dimeric Aporphine-Benzylisoquinoline and Aporphine-Pavine Alkaloids

Journal of Natural Products, 1979
Hélène, Guinaudeau, Michel, Leboeuf, André, Cavé   +2 more
openaire   +2 more sources