Results 11 to 20 of about 492 (130)

Antimicrobial Activity and Chemical Constituents of Siparuna guianensis (Siparunaceae). [PDF]

Chem Biodivers
ABSTRACT Siparuna guianensis (Siparunaceae) is an Amazonian plant known by the popular name of Negramina. There are several reports of the use of this plant in folk medicine. In the present work, we decided to study its extracts, aiming at the isolation of compounds and verifying their antimicrobial activities.
Vilanculo OMM, Pinheiro MSDS, de Oliveira LC, de Souza DAA, Cardoso SVD, Silva SDC, Marinho PSB, do Rosario Marinho AM.   +7 more
europepmc   +2 more sources

Phytochemicals From <i>Houttuynia cordata</i> Thunb as Potential Inhibitors of BRAF, MEK, and ERK: Insights From Molecular Docking. [PDF]

J Skin Cancer
This study utilized molecular docking techniques to investigate the potential of phytochemical compounds in Houttuynia cordata Thunb. extract as inhibitors of the oncogenic MAPK signaling pathway in melanoma. The docking results revealed that several phytochemical compounds exhibited favorable binding interactions with the BRAFV600E, MEK, and ERK ATP ...
Yanarojana M, Tancharoen S, Nararatwanchai T, Yanarojana S.   +3 more
europepmc   +2 more sources

Lineage-Specific CYP80 Expansion and Benzylisoquinoline Alkaloid Diversity in Early-Diverging Eudicots. [PDF]

Adv Sci (Weinh)
Herein, a chromosome‐level genome assembly of Menispermum dauricum is presented. A novel MdCYP80G10 enzyme is identified to catalyze C2′‐C4a phenol coupling of (S)‐reticuline into sinoacutine, the enantiomer of morphinan compounds, with predictable stereospecificity.
An Z, Gao R, Chen S, Tian Y, Li Q, Tian L, Zhang W, Kong L, Zheng B, Hao L, Xin T, Yao H, Wang Y, Song W, Hua X, Liu C, Song J, Fan H, Sun W, Chen S, Xu Z.   +20 more
europepmc   +2 more sources

Cytotoxic Aporphines from Artabotrys Crassifolius [PDF]

Natural Product Communications, 2016
Artabotrys crassifolius Hook. f. & Thomson is a medicinal plant used in Malaysia. The cytotoxic effects of the hexane, chloroform and ethanol extracts of the leaves and bark were examined in vitro against MCF-7, MDA-468 and HCT-116 cells. The chloroform extract of the bark inhibited the growth of all cell lines with GI50 values ranging from 4.2 μg/
Tan Kok, Kwan, Fiona, Shipton, Nadiah Syafiqah Nor, Azman, Shahadat, Hossan, Khoo Ten, Jin, Christophe, Wiart   +5 more
openaire   +2 more sources

Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Serotonin (5-HT) is an important regulator of numerous aspects of flatworm biology, ranging from neuromuscular function to sexual maturation and egg laying.
Jonathan S. Marchant, Wayne W. Harding, John D. Chan   +2 more
doaj   +1 more source

Stephanine Protects Against Osteoporosis by Suppressing Osteoclastogenesis via Inhibition of the RANKL-RANK Interaction. [PDF]

J Cell Mol Med
ABSTRACT The interaction between the receptor activator of nuclear factor‐κB ligand (RANKL) and its receptor RANK is known to regulate osteoclastogenesis in bone remodelling and has become an important therapeutic target for the treatment of osteoporosis. Stephanine (SA), an isoquinoline aporphine‐type alkaloid isolated from Stephania plants, possesses
Liu T, Li J, Duan M, Wang Y, Jiang Z, Gan C, Xiang Z, Sheng J, Wang X, Xu H.   +9 more
europepmc   +2 more sources

Syntheses of (±)-Romucosine and (±)-Cathafiline [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2006
The structures previously assigned to (-)-romucosine and (+)-cathafiline, N-(methoxycarbonyl) aporphine alkaloids from Rollina mucosa (Annonaceae) and Cassytha filiformis (Lauraceae) respectively, have been confirmed by total syntheses of the racemic ...
Surachai Nimgirawath
doaj  

Studies on the Alkaloids of the Bark of Magnolia officinalis: Isolation and On-line Analysis by HPLC-ESI-MSn

Molecules, 2013
The bark of Magnolia officinalis is a well-known Traditional Chinese Medicine. In the present study, two new alkaloids, named (S)-4-keto-magnoflorine (6) and (R)-3,4-dehydromagnocurarine (11), together with seven known alkaloids: (S)-magnoflorine (5 ...
Renyi Yan, Weihao Wang, Jian Guo, Hongliang Liu, Jianyong Zhang, Bin Yang   +5 more
doaj   +1 more source

LC-MS/MS BASED DEREPLICATION OF ISOQUINOLINE-DERIVED ALKALOIDS FROM THE TRUNK BARK OF Unonopsis rufescens (Baill.) R.E.Fr. (Annonaceae) [PDF]

Química Nova
Mass spectrometry-based approaches constitute the primary strategy for the dereplication of isoquinoline-derived alkaloids, which are widely distributed in various genera of the Annonaceae family.
Lucas Antônio F. de Almeida, Felipe Moura A. da Silva, Bruna Ribeiro de Lima, Aline Bastos B. de Sousa, Francinaldo A. da Silva Filho, Brenda R. C. Leocadio, Ana Paula A. Castro, Rebeca dos S. França, Hector H. F. Koolen, Afonso D. L. de Souza, Maria Lúcia B. Pinheiro   +10 more
doaj   +1 more source

A systematic review of proaporphine alkaloids and a pharmacological update

Phytomedicine Plus
Background: Proaporphine alkaloids are present in many plant families. They are often considered as metabolic precursors to aporphines. They generally contain a cyclohexadienone system and can rearrange to aporphines on treatment with acid.
Christian Bailly
doaj   +1 more source