Results 111 to 120 of about 2,633 (292)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2013 The issue of intended audience in the first three books of Augustine’s Confessions is investigated in light of the presence of terms and phrases that may have had special connotations for potential Manichaean readers.
Annemaré Kotzé
doaj +2 more sources
Understanding insomnia as systemic disease. [PDF]
Yeungnam Univ J Med, 2021 Yun S, Jo S.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
سزا ئے ارتداد کی معاصرتعبیر و تفہیم کاتجزیاتی مطالعہ(مسلم مفکرین کی آرا کی روشنی میں)
Pakistan Journal of Islamic ResearchThis study aims to examine the historical background of the debate on punishments to apostates that are established in classical Islamic texts. This study indeed analyzes thethought, that majority of Muslim jurists have founded their claim that the ...
Faridah Yousuf
doaj
The traumatic consequences of Boko Haram slavery among the ethnic minorities of southern Borno, Borno State, Nigeria. [PDF]
Afr J Prim Health Care Fam Med, 2022 Ziradzo S, Netangaheni RT.
europepmc +1 more source