Results 131 to 140 of about 532 (257)

Evaluation of the inhibitory potential of Bioactive compounds against SARS-CoV2 by in-silico approach

, 2023
J MSR, P A, V N, Mohan S, Rao RM, PD R, Muthulakshmi L.   +6 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Lysine acetylation modulates s-OPA1 GTPase activity and oligomerization in mitochondrial membrane remodeling. [PDF]

Protein Sci
Jabbar J, Afroze B, Ling NXY, Oakhill JS, Rouiller I.   +4 more
europepmc   +1 more source

Protein-Interaction Affinity Gradient Drives [4Fe-4S] Cluster Insertion in Human Lipoyl Synthase. [PDF]

J Am Chem Soc, 2022
Saudino G, Ciofi-Baffoni S, Banci L.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mechanism of modulation of AMPA receptors by TARP-γ8. [PDF]

J Gen Physiol, 2020
Carrillo E, Shaikh SA, Berka V, Durham RJ, Litwin DB, Lee G, MacLean DM, Nowak LM, Jayaraman V.   +8 more
europepmc   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Broad PFAS Binding with Fatty Acid Binding Protein 4 Is Enabled by Variable Binding Modes. [PDF]

JACS Au
Birchfield AS, Musayev FN, Castillo AJ, Zorn G, Fuglestad B.   +4 more
europepmc   +1 more source

Multi-Ideology, Multiclass Online Extremism Dataset, and Its Evaluation Using Machine Learning. [PDF]

Comput Intell Neurosci, 2023
Gaikwad M, Ahirrao S, Phansalkar S, Kotecha K, Rani S.   +4 more
europepmc   +1 more source