Results 121 to 130 of about 1,812,730 (293)

Cell competition in primary and metastatic colorectal cancer

Oncogenesis
Adult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker “loser” cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis.
Merel Elise van Luyk, Ana Krotenberg Garcia, Maria Lamprou, Saskia Jacoba Elisabeth Suijkerbuijk   +3 more
doaj   +1 more source

Grand Canyon Student Map Competition Award Ceremony – Video Recording

, 2019
: Students were invited to submit their original cartographic work to the 2019 Mapping Grand Canyon Student Map Competition. Three categories of cartographic production were considered for this competition.

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Apparent cooperativity between human CMV virions introduces errors in conventional methods of calculating multiplicity of infection

eLife
Whether infection of cells by individual virions occurs randomly, or if there is some form(s) of competition or cooperativity between individual virions, remains largely unknown for most virus–cell associations. Here, we studied cooperativity/competition
Christopher Peterson, Joshua Miller, Brent Ryckman, Vitaly V Ganusov   +3 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Disease persistence and apparent competition in a three-host community: an empirical and analytical study of large-scale, wild populations

, 2001
1. We investigated the effects of three types of host on the persistence of a tick-borne virus, using the grouse-hare-deer-tick-louping ill virus system of upland Britain. Each host differed in its interaction with the vector and pathogen. Grouse amplify
Laurenson, K. M., Hudson, P. J., Gilbert, Lucy, Laurenson, KM, Reid, HW, Hudson, Peter J, K. M. Laurenson, Norman, Rachel, Reid, Hugh W, Reid, H. W., Hudson, PJ, Laurenson, M Karen, L. Gilbert, R. Norman, P. J. Hudson, Norman, R, Norman, R., H. W. Reid   +17 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Food Web Assembly Rules for Generalized Lotka-Volterra Equations.

PLoS Computational Biology, 2016
In food webs, many interacting species coexist despite the restrictions imposed by the competitive exclusion principle and apparent competition. For the generalized Lotka-Volterra equations, sustainable coexistence necessitates nonzero determinant of the
Jan O Haerter, Namiko Mitarai, Kim Sneppen   +2 more
doaj   +1 more source

Apparent competition between major pests reduces pest population densities on tomato crop, but not yield loss

, 2015
Increased pest control by generalist predators has been successfully achieved in several cases by promoting apparent competition, which is the reciprocal negative interactions between prey mediated by their shared predator.
Bearez, Philippe, Coline C. Jaworski, Nicolas Desneux, Philippe Bearez, Jaworski, Coline, C, Desneux, Nicolas, Anaïs Chailleux, Jaworski, Coline C., Chailleux, Anaïs   +8 more
core   +1 more source