Results 61 to 70 of about 1,751,270 (289)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Ecosphere, 2019 In Canada, boreal caribou (Rangifer tarandus caribou) are declining in numbers, in part due to increased predation by wolves (Canis lupus). One management option to reduce wolf–caribou interactions and thus protect caribou is to remove man‐made linear ...
Matthias C. Spangenberg +6 more
doaj +1 more source
Understanding the Impact of Scale Height on the Kinetics and Kinematics of Dogs in Working Trials
Frontiers in Veterinary Science, 2022 Working trials is a canine discipline that originated from police and military dog work. One aspect of working trials competition is for a dog to “scale” a 6ft high wooden wall.
Anne Carter +2 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
2020 International BCI Competition
, 2022 2020 International BCI competition ...
BCI Competition Committee
core +1 more source
Seasonal variation in the utility of a status signaling system: Plumage ornament predicts foraging success only during periods of high competition. [PDF]
PLoS ONE, 2017 Status signals allow competitors to assess each other's resource holding potential and reduce the occurrence of physical fights. Because status signals function to mediate competition over resources, a change in the strength of competition may affect the
Philip S Queller, Troy G Murphy
doaj +1 more source
The Role of Immune‐Mediated Apparent Competition in Genetically Diverse Malaria Infections [PDF]
The American Naturalist, 2006 Competitive interactions between coinfecting genotypes of the same pathogen can impose selection on virulence, but the direction of this selection depends on the mechanisms behind the interactions. Here, we investigate how host immune responses contribute to competition between clones in mixed infections of the rodent malaria parasite Plasmodium ...
Råberg, Lars +5 more
openaire +4 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source