Results 81 to 90 of about 1,751,270 (289)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Competition Order and Innovation Behaviors of Enterprise in China

Discrete Dynamics in Nature and Society, 2020
This study addresses the apparent puzzle that China made great progress in mobile phone manufacturing despite weak intellectual property protection.
Weijun Cui, Guang Chen, Yu Fu
doaj   +1 more source

Density-dependent indirect effects: apparent mutualism and apparent competition coexist in a two-prey system [PDF]

Marine Ecology Progress Series, 2012
A predator consuming multiple prey species usually causes indirect effects. Apparent mutualism results when multiple prey species reduce predation risk for each other by altering a predator's functional response. Short-term apparent competition occurs when multiple prey species increase predation risks for each other through the numerical response, i.e.
Long, W. Christopher, Gamelin, Emily F., Johnson, Eric G., Hines, Anson H.   +3 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

When is habitat recovered? Understanding the mechanisms of population decline to evaluate habitat recovery for boreal caribou

Conservation Science and Practice
Recovering habitat is a central objective for conserving species imperiled by habitat alteration. Yet, determining when habitat is recovered is challenging.
Craig A. DeMars, Melanie Dickie, Doug W. Lewis, Thomas J. Habib, Mark M. Wong, Robert Serrouya   +5 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Wildlife following people: A multidisciplinary assessment of the ancient colonization of the Mediterranean Basin by a long‐lived raptor

People and Nature
Modern humans widely shaped present ecosystems through intentional and unintentional geographical redistribution of wildlife, both in historical and pre‐historical times.
Marcos Moleón, Eva Graciá, Nuria García, José M. Gil‐Sánchez, Raquel Godinho, Pedro Beja, Luís Palma, Joan Real, Antonio Hernández‐Matías, A. Román Muñoz, Eneko Arrondo, José A. Sánchez‐Zapata   +11 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Where Dinner Roams: The Role of Feral Horses as a Resource Subsidy for Wolves and Cougars in West‐Central British Columbia

Ecology and Evolution
Feral horses (Equus ferus caballus) have established large populations in west‐central British Columbia (BC), Canada, where they overlap with native ungulates, including a declining woodland caribou (Rangifer tarandus caribou) herd.
Shane C. White, Julie Thomas, Carolyn Shores, Kathi Zimmerman   +3 more
doaj   +1 more source