Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Nutrient digestibility, nitrogen balance, and energy partitioning in laying hens subjected to different molt induction programs. [PDF]
Poult SciJuárez A +7 more
europepmc +1 more source
Advanced Science, EarlyView.This study developed an efficacy assessment platform that integrates patient‐derived gastric cancer organoids, atomic force microscopy (AFM)‐based nanomechanical vibration detection, deep learning analysis, and organoid mechanical modeling. It detects picomolar drug effects within 0.1 s signal, achieves 97% classification accuracy, and offers non ...
Ting Zhang +10 more
wiley +1 more source
Fermented Pangasius Catfish Waste Improves Energy Utilization and Nutrient Digestibility in Low-Protein Diets for Indonesian Super Native Chickens. [PDF]
Vet Med SciAbun A, Haetami K, Ramdhan RF.
europepmc +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Metabolizable and Net Energy Values of Corn from Various Regions and Prediction Equation Development for Arbor Acres Broilers at Two Growth Stages. [PDF]
Animals (Basel)Guo X, Li L, Yin S, Ban Z, Nie W.
europepmc +1 more source
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury
Advanced Science, EarlyView.This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang +7 more
wiley +1 more source
Effects of Feeding Sunflower Meal and Superdosing Phytase on the Production Traits and Nutrient Digestion of Broiler Chickens. [PDF]
Animals (Basel)Tewelde KG +6 more
europepmc +1 more source
Influence of dietary energy level and corn particle size on performance, nutrient digestibility, and gut development in broilers fed pelleted diets. [PDF]
Poult SciSihite M +4 more
europepmc +1 more source
Metabolizable Energy, Standardized Ileal Digestible Amino Acids, Standardized Total Tract Digestible Phosphorus, and Replacement Value of Full-Fat Almonds for Pigs. [PDF]
Animals (Basel)Hwang Y, Kim JW, Kim BG.
europepmc +1 more source