Results 41 to 50 of about 124,745 (257)
Pharmaceuticals, 2021 To improve physicochemical properties of vardenafil hydrochloride (VAR), its amorphous form and combinations with excipients—hydroxypropyl methylcellulose (HPMC) and β-cyclodextrin (β-CD)—were prepared.
Gabriela Wiergowska +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Energies, 2020 Injecting carbon dioxide to enhance shale gas recovery (CO2-EGR) is a useful technique that has raised great research interests. Clear understanding of the two-component gas transport mechanisms in shale nanopores is the foundation for the efficient ...
Chaohua Guo +3 more
doaj +1 more source
Degree of Dietary Refinement Alters Apparent Gut Permeability
The FASEB Journal, 2018 Previous studies in our lab showed less refined diets reduced gut permeability (GI‐p) as assessed by 4hr plasma FITC‐dextran (FITC‐d) concentration in conjunction with reduced adiposity. To determine if degree of dietary refinement altered gut health and lipoprotein biology, we conducted a 14 week feeding trial in which weanling ...
Tara R. Price, Rosemary L. Walzem
openaire +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Pharmaceutics, 2023 Permeability has an important effect on drug absorption. In this study, the effect of different concentrations of sodium sulfobutyl ether-β-cyclodextrin (SBE-β-CD) on the absorption of ranitidine was investigated to examine the mechanism of permeability ...
Rui Yang +5 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Effects of porosity and inertia on the apparent permeability tensor in fibrous media [PDF]
International Journal of Multiphase Flow, 2018 The flow in three-dimensional fibrous porous media is studied in the inertial regime by first simulating for the motion in unit, periodic cells, and then solving successive closure problems leading – after applying an intrinsic averaging procedure – to the components of the apparent permeability tensor.
Luminari, Nicola +2 more
openaire +4 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Meitan kexue jishuThe apparent permeability of gas-water two-phase flow in the inorganic shale pore system of shale is a critical parameter for evaluating shale gas production and the flowback rate of fracturing fluid, and its accurate characterization provides a ...
Rui YANG +3 more
doaj +1 more source