Results 51 to 60 of about 124,745 (257)

Oral delivery of lipophilic drugs: the tradeoff between solubility increase and permeability decrease when using cyclodextrin-based formulations. [PDF]

PLoS ONE, 2013
The purpose of this study was to investigate the impact of oral cyclodextrin-based formulation on both the apparent solubility and intestinal permeability of lipophilic drugs.
Avital Beig, Riad Agbaria, Arik Dahan
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Influences of adsorption/desorption of shale gas on the apparent properties of matrix pores

Petroleum Exploration and Development, 2016
: The adsorption/desorption effects impact the petro-physical properties of matrix pores during gas depressurizing production, such as effective pore radius, effective porosity, apparent permeability, which will further impact the gas flow regime.
Jing WANG, Haishan LUO, Huiqing LIU, Jie LIN, Liwen LI, Wenxin LIN   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Layer recombination technique for waterflooded low-permeability reservoirs at high water cut stage

Journal of Petroleum Exploration and Production Technology, 2018
Layer recombination is an important technique to improve the oil recovery of waterflooded low-permeability reservoirs, especially at high water cut stage.
Chuanzhi Cui, Zhongwei Wu
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Productivity evaluation of multi-stage fracturing horizontal wells in shale gas reservoir with complex artificial fracture occurrence

Youqicang pingjia yu kaifa, 2023
Considering complex shape and non-uniform distribution of fracturing fractures in shale reservoir, on the basis of multiple migration mechanisms a unified apparent permeability model is developed, incorporating two types of pore apparent permeability ...
HU Zhijian, LI Shuxin, WANG Jianjun, ZHOU Hong, ZHAO Yulong, ZHANG Liehui   +5 more
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Hydrostratigraphy of the Bauru Group in São Paulo State, Brazil

Revista Águas Subterrâneas, 2005
Geophysical logs, ditch samples and cores of water wells drilled in São Paulo State, Brazil, allowed the identification and correlation of different hydrostratigraphics units and the evaluation of hydraulic potential of the Bauru Aquifer System (Mesozoic
Flávio de Paula e Silva, Chang Hung Kiang, Maria Rita Caetano-Chang   +2 more
doaj   +1 more source

Features of measuring absolute permeability of rocks

Вестник Самарского государственного технического университета. Серия: Технические науки, 2020
Aspects of gas permeability measurement on samples of terrigenic and carbonate rocks of oil and gas collectors, as well as artificial samples on the domestic Darsimeter plant are considered. The following types of reservoir rocks were used for the study:
Aleksander V. Pescov
doaj   +1 more source