Results 81 to 90 of about 299,045 (318)

The Regulatory Role of Apelin on the Appetite and Growth of Common Carp (Cyprinus Carpio L.)

Animals, 2020
Apelin, a kind of active polypeptide, has many biological functions, such as promoting food intake, enhancing immunity, and regulating energy balance. In mammals, studies have indicated that apelin is involved in regulating food intake.
Xiao Yan, Chaobin Qin, Guokun Yang, Dapeng Deng, Liping Yang, Junchang Feng, Jiali Mi, Guoxing Nie   +7 more
doaj   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

A bidirectional network for appetite control in larval zebrafish

eLife, 2019
Medial and lateral hypothalamic loci are known to suppress and enhance appetite, respectively, but the dynamics and functional significance of their interaction have yet to be explored.
Caroline Lei Wee, Erin Yue Song, Robert Evan Johnson, Deepak Ailani, Owen Randlett, Ji-Yoon Kim, Maxim Nikitchenko, Armin Bahl, Chao-Tsung Yang, Misha B Ahrens, Koichi Kawakami, Florian Engert, Sam Kunes   +12 more
doaj   +1 more source

Differential Roles of Two Leptin Gene Paralogues on Food Intake and Hepatic Metabolism Regulation in Mandarin Fish

Frontiers in Endocrinology, 2020
Leptin affects food intake regulation and energy homeostasis in mammals, as opposed to mammals who have a single leptin gene, fish have duplicated leptin gene paralogues.
Xiao-Chen Yuan, Xiao-Chen Yuan, Xu-Fang Liang, Xu-Fang Liang, Wen-Jing Cai, Wen-Jing Cai, Ai-Xuan Li, Ai-Xuan Li, Dong Huang, Dong Huang, Shan He, Shan He   +11 more
doaj   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

A magnetic resonance imaging and gut flora-based study of intake desire in overweight/obese type 2 diabetes mellitus patients

Frontiers in Neuroscience
BackgroundAbnormal regulation of food intake in overweight/obese type 2 diabetes mellitus (T2DM) patients is an important cause of energy intake imbalance, and studies have demonstrated that the “gut-brain axis” is involved in a wide range of metabolic ...
Mingxuan Gao, Liya Gong, Yanmei Zeng, Dongling Li, Junyan Wen, Ying Guo, Zhujia Li, Jingwen Luo, Chunling Chen, Ge Wen   +9 more
doaj   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Effectiveness of an innovative oral hygiene product in patients with obesity and type 2 diabetes mellitus in regulating appetite and food preferences

Consilium Medicum
Background. Diabetes mellitus (DM) and obesity are diseases that lead to systemic complications that shorten life expectancy and reduce quality of life. Treatment and control of these diseases can reduce the risk of complications.
Fatima K. Dzgoeva, Elena A. Karton, Irina G. Ostrovskaya, Ekaterina A. Shestakova, Anastasiia V. Anokhina, Marina V. Shestakova   +5 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Estradiol modulates the palatability of 0.3 M NaCl in female rats during sodium appetite

, 2019
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Estadual PaulistaProcesso FAPESP: 2015/20500 ...
De Luca, L. A., Andrade, C. A.F. [UNESP], Dantas, R. M. [UNESP], Andrade-Franzé, G. M.F. [UNESP], Dantas, R. M., Andrade, C. A.F., Menani, J. V., Pereira, E. D., Pereira, E. D. [UNESP], Andrade-Franzé, G. M.F., De Luca, L. A. [UNESP], Menani, J. V. [UNESP]   +11 more
core   +1 more source