Results 91 to 100 of about 30,090,884 (357)

Foodomics Applications

open access: yes, 2018
Foodomics is the discipline that studies the food and nutrition domains through the application and integration of advanced omics technologies. This chapter summarizes the different strategies used in Foodomics for data analysis as well as the existing limitations and challenges that still need to be overcome in this new discipline.
León, Carlos   +2 more
openaire   +2 more sources

Detecting attitude change with the implicit association test [PDF]

open access: yes
The Implicit Association Test and its variants have become pervasive measures of attitudes in a variety of domains and contexts. In two experiments, the authors provide evidence that a recent variant, the Personalized IAT developed by Olson and Fazio ...
CZELLAR, Sandor, FAZIO, Russell H.
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Progress of the discovery, application, and control technologies of chemical pesticides in China

open access: yesJournal of Integrative Agriculture, 2019
Pesticides, which have the dual characteristics of being both helpful and harmful, are important materials for ensuring food security and human health. Therefore, the rational development, scientific application, and effective control of pesticides are ...
Xing-lu PAN   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Progress in Research on Metal Ion Crosslinking Alginate-Based Gels

open access: yesGels
Alginate is an important natural biopolymer and metal ion-induced gelation is one of its most significant functional properties. Alginate-based hydrogels crosslinked with metal ions are commonly utilized in the food, biomedical, tissue engineering, and ...
Yantao Wang   +7 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The role of Criticism in the Dynamics of Performance Evaluation Systems [PDF]

open access: yes
Drawing on the concept of « trial », developed by French sociologists, this article analyzes the dynamics of employees’ performance evaluation systems, particularly those involving accounting performance measures.
Annick, BOURGUIGNON, Eve, CHIAPELLO
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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