Results 111 to 120 of about 828,151 (209)
Phage Therapy: Application and Related Problems—A Review
LifeBacteriophages, viruses that target bacteria, offer a promising alternative to antibiotics in the face of escalating bacterial resistance. Despite their discovery over a century ago, their widespread adoption has been impeded by regulatory challenges ...
Katharina Sippel, Branko Velimirov
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Environmental and industrial application of chitosan nanocomposites: review
Discover ChemistryThis review extensively evaluates recent advances in chitosan-based nanocomposites for environmental remediation and sensing applications. The scope covers synthesis methodologies, structural modifications, and performance evaluation of chitosan ...
shaheeda Adonis +2 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Injuries in strength training: review and practical application
European Journal of Human Movement, 2014 Purpose: This systematic review examines what is known about injuries in strength training. Methods: A systematic search was performed in PubMed and SportDiscus.
Javier Butragueño +2 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
European Medical JournalGadolinium-based contrast agents (GBCA) have played a pivotal role in enhancing the diagnostic capabilities of MRI for several decades. The application of gadolinium as a contrast agent opened new possibilities for early diagnosis with greater accuracy ...
Moh. Tawhid Islam, Vera Tsnobiladze
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Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
CYCLODEXTRINS AND THEIR APPLICATION IN PHARMACEUTICAL INDUSTRY (REVIEW)
Разработка и регистрация лекарственных средств, 2019 In the review describes the main properties of cyclodextrins and their potential use in the formulations in various dosage forms as excipients, by which it becomes possible to modify the solubility of drugs, increase the bioavailability and stability of ...
S. A. Kedik +3 more
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