Results 131 to 140 of about 7,720,058 (280)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Influence of gut microecology in the development of malignant tumors and its potential therapeutic application: A review. [PDF]
Medicine (Baltimore), 2023 Qian JP +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Injuries in strength training: review and practical application
European Journal of Human Movement, 2014 Purpose: This systematic review examines what is known about injuries in strength training. Methods: A systematic search was performed in PubMed and SportDiscus.
Javier Butragueño +2 more
doaj
Photocatalytic Material-Microorganism Hybrid System and Its Application-A Review. [PDF]
Micromachines (Basel), 2022 Song J, Lin H, Zhao G, Huang X.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Recent Development of Nano-Carbon Material in Pharmaceutical Application: A Review. [PDF]
Molecules, 2022 Jiwanti PK +5 more
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
CYCLODEXTRINS AND THEIR APPLICATION IN PHARMACEUTICAL INDUSTRY (REVIEW)
Разработка и регистрация лекарственных средств, 2019 In the review describes the main properties of cyclodextrins and their potential use in the formulations in various dosage forms as excipients, by which it becomes possible to modify the solubility of drugs, increase the bioavailability and stability of ...
S. A. Kedik +3 more
doaj
Artificial Intelligence-Based Consumer Health Informatics Application: Scoping Review.
J Med Internet Res, 2023 Asan O, Choi E, Wang X.
europepmc +1 more source