Results 231 to 240 of about 7,720,058 (280)

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

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GWO: a review and applications

International Journal of System Assurance Engineering and Management, 2020
From the solitudinarian era to the present, the human race has been striving towards the betterment of his life by trying to find out the hidden secrets of our nature. Some time back one would hardly think that colonies of ant, pack of grey wolves, and elephants would be used to design an optimization algorithm.
Ganga Negi, Anuj Kumar, Sangeeta Pant, Mangey Ram   +3 more
openaire   +1 more source

Metaheuristics: review and application

Journal of Experimental & Theoretical Artificial Intelligence, 2013
The area of metaheuristics has grown immensely in the past two decades as a solution to real-world optimisation problems. They are able to perform well in situations where exact optimisation techniques fail to deliver satisfactory results. For complex optimisation problems (Nondeterministic polynomial time-hard problems), metaheuristic techniques are ...
Anupriya Gogna, Akash Tayal
openaire   +1 more source

Monoolein: A Review of the Pharmaceutical Applications

Drug Development and Industrial Pharmacy, 2000
Although monoolein is a well-known molecule commonly used as an emulsifying agent and as a food additive since the 1950s, its potential applicability in the pharmaceutical industry has not been con...
Ganem-Quintanar, Adriana, Quintanar-Guerrero, David, Buri, Pierre   +2 more
openaire   +3 more sources

Applications Reviews

Interfaces, 1984
“Applications Reviews” is a guide to accomplished or partial MS/OR applications, cited in articles appearing in many of the major journals of the field. We cover only applications—except for the occasional brief mention of a survey article or special issue—and so do not claim to cover all the best articles in MS/OR.
John R. Hall, Roger N. Millen, Vicki L. Sauter, Russell S. Winer, Charles Dale   +4 more
openaire   +1 more source

Applications Reviews

Interfaces, 1981
An overview of recent articles from Growth and Change, Decision Sciences (AIDS), Management Science, MIS Quarterly (SMIS/MISRC), Operations Research, Policy Analysis, Policy Sciences, Regional Science and Urban Economics, and Socio-Economic Planning Sciences.
Roger N. Millen, John R. Hall, Vicki L. Sauter   +2 more
openaire   +1 more source