Results 121 to 130 of about 196,133 (310)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Domain Modeling of Time-Dependent Systems

, 1993
This research investigated the feasibility of composing time-dependent specifications in Architect, a domain-oriented application composition and generation system being developed at the Air Force Institute of Technology (AFIT).
Waggoner, Robert W.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Process equipment modeling using the moment method [PDF]

, 2010
Process equipment models are needed in all stages of chemical process research and design. Typically, process equipment models consist of systems of partial differential equations for mass and energy balances and complicated closure models for mass ...
Roininen, Jonas
core  

A joint frailty model to estimate the recurrence process and the disease-specific mortality process without needing the cause of death.

, 2014
In chronic diseases, such as cancer, recurrent events (such as relapses) are commonly observed; these could be interrupted by death. With such data, a joint analysis of recurrence and mortality processes is usually conducted with a frailty parameter ...
Roch Giorgi, Belot, Aurélien, Remontet, Laurent, CENSUR working survival group, Giorgi, Roch, Virginie Rondeau, Rondeau, Virginie, Laurent Remontet, Aurélien Belot   +8 more
core   +1 more source

SARX Model Application for Industrial Power Demand Forecasting in Brazil

Revista Sociedade, Contabilidade e Gestão, 2012
The objective of this paper is to propose the application of the SARX model to arrive at industrial power consumption forecasts in Brazil, which are critical to support decision-making in the energy sector, based on technical, economic and ...
Alessandra de Ávila Montini, João Bosco B. de Castro   +1 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Littoral undersea warfare: a case study in process modeling for functionality and interoperability of complex systems

, 2007
The goal of this work was to demonstrate the application of a process modeling approach to architect a system of systems (SoS) capable of conducting anti-submarine (undersea) warfare (ASW) operations projecting to the year 2025.
Boensel, M., Strunk, J., Vaidyanathan, R, Boensel, M, Shoup, F, Vaidyanathan, R., Strunk, J, Shoup, F., Bacon, R, Baker, J., Bindi, V, Bindi, V., Baker, J, Bacon, R.   +13 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Research on Batik Dyeing Process of Vegetable-tanned Cowhide Leather based on Human Factors Engineering-mechanical System Mapping

Pige Kexue Yu Gongcheng
ObjectiveThe batik painting process in traditional batik dyeing is highly dependent on the personal experience of craftsmen, and there are some problems such as high technical threshold, long painting time, difficulty in maintaining consistency of ...
Gang TANG, Tingting WANG, Yunhe YAO, Tao ZHOU, Jinyong SU   +4 more
doaj   +1 more source