Results 131 to 140 of about 196,133 (310)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Four notions of mean preserving increase in risk, risk attitudes and applications to the Rank-Dependent Expected Utility model [PDF]
This article presents various notions of risk generated by the intuitively appealing single-crossing operations between distribution functions. These stochastic orders, Bickel & Lehmann dispersion or (its equal-mean version) Quiggin's monotone mean ...
Michèle Cohen +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
PANEL DATA DOUBLE-HURDLE MODEL: AN APPLICATION TO DAIRY ADVERTISING
In this study, we extend to panel data structures the double-hurdle model typically used in cross-sectional data. The new double-hurdle model can account not only for the censored nature of commodity purchases, but also for the dynamics of the purchase ...
Chung, Chanjin +2 more
core
Shocks in homogeneous and heterogeneous populations [PDF]
A system subject to a point process of shocks is considered. Shocks occur in accordance with a nonhomogeneous Poisson process. Different criterions of system failures are discussed in a homogeneous case. Two natural settings are analyzed.
Maxim S. Finkelstein
core
DropletBioparticle manipulation is vital for diagnostics, therapeutics, and biological research. Microfluidic technology provides high throughput and precise control, yet traditional methods using Newtonian fluids face challenges like cell damage due to high ...
Huan Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Supporting Focus and Context Awareness in 3D Modeling Using Multi-Layered Displays
, 2013 Although advances in computer technology over the past few decades have made it possible to create and render highly realistic 3D models these days, the process of creating these models has remained largely unchanged over the years.
Mohd Yusof, Azmi
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source