Results 51 to 60 of about 196,133 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Electrochemical performance study of Ag/AgCl and Au flexible electrodes for unobtrusive monitoring of human biopotentials

Nano Select, 2022
Flexible and stretchable electronics are a logical choice for the recording of biopotentials, due to their improved patient comfort and customizability. There is, however, significant variance in the signal quality received from these electrodes based on
Jonas F. Kurniawan, Alexis B. Allegra, Timothy Pham, Andrew K. L. Nguyen, Nathan L. J. Sit, Boris Tjhia, Andrew J. Shin, Todd P. Coleman   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A Neighborhood Search for Sequence-dependent Setup Time in Flow Shop Fabrics Making of Textile Industry [PDF]

, 2011
This paper proposes a neighborhood search to solve scheduling for fabrics making in a textile industry. The production process consists of three production stages from spinning, weaving, and dyeing. All stages have one processor.
Totong,, Kurniawan, Bobby, Sumihartati, Atin   +2 more
core  

The Touchard Process for Count Data with Dependent Increments

Mathematics
This paper introduces the Touchard process, a flexible two-parameter stochastic framework for modeling count data that depart from the classical Poisson assumptions.
Moisés Lima, Gladston Da Silva, Regina Da Fonseca, Raul Matsushita   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Analytical Formula for the Transition Density of a Conic Combination of Independent Squared Bessel Processes with Time-Dependent Dimensions and Financial Applications

Mathematics
The squared Bessel process plays a central role in stochastic analysis, with broad applications in mathematical finance, physics, and probability theory.
Nopporn Thamrongrat, Chhaunny Chhum, Sanae Rujivan, Boualem Djehiche   +3 more
doaj   +1 more source

Felt Accountability and Managerial Performance: The Moderation Effects of Organizational Commitment and Work Motivation (Empirical Study on Medical Managers of Community Health Centers in Pemalang Regency) [PDF]

SHS Web of Conferences
This research aims to scrutinize the effect of felt accountability on managerial performance with organizational commitment and work motivation as moderating variables.
Munasifa Naelal, Pratolo Suryo
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Understanding predictive uncertainty in hydrologic modeling: The challenge of identifying input and structural errors

, 2009
Meaningful quantification of data and structural uncertainties in conceptual rainfall-runoff modeling is a major scientific and engineering challenge. This paper focuses on the total predictive uncertainty and its decomposition into input and structural ...
Thyer, M., Kavetski, D., Renard, B., Renard, Benjamin, Franks, S., Kuczera, G.   +5 more
core   +1 more source