Results 61 to 70 of about 196,133 (310)

Subclass problem-dependent design for error-correcting output codes [PDF]

, 2008
A common way to model multiclass classification problems is by means of Error-Correcting Output Codes (ECOCs). Given a multiclass problem, the ECOC technique designs a code word for each class, where each position of the code identifies the membership of
Radeva, Petia, Pujol Vila, Oriol, Escalera Guerrero, Sergio, Tax, David M. J., Duin, Robert P. W.   +4 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Stochastic simulation of woven composites forming [PDF]

, 1995
A stochastic forming simulation procedure is developed and implemented to investigate the effect of geometric variability in pre-impregnated woven textiles on manufacturing. Image analysis is used to characterise variability in tow directions and unit
Waal, de, H., Skordos, Alexandros A., Simons, D.R., Faber, A.J., Schaeffer, H.A., Sutcliffe, Michael P. F.   +5 more
core   +1 more source

Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

Pharmaceutics
The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process ...
Junjie Cao, Haoran Shen, Shuying Zhao, Xiao Ma, Liping Chen, Shengyun Dai, Bing Xu, Yanjiang Qiao   +7 more
doaj   +1 more source

A comprehensive study on battery electric modeling approaches based on machine learning

Energy Informatics, 2021
Battery electric modeling is a central aspect to improve the battery development process as well as to monitor battery system behavior. Besides conventional physical models, machine learning methods show great potential to learn this task using in ...
Felix Heinrich, Patrick Klapper, Marco Pruckner   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Numerical analysis of the hydrodynamic behaviour of immiscible metallic alloys in twin-screw rheomixing process

, 2006
A numerical analysis by a VOF method is presented for studying the hydrodynamic mechanisms of the rheomixing process by a twin-screw extruder (TSE). The simplified flow field is established based on a systematic analysis of flow features of immiscible ...
Tang, H, L.C. Wrobel, H. Tang, Z. Fan, Wrobel, L C, Fan, Z   +5 more
core   +1 more source

Drug Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin [PDF]

, 2009
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force.
Torres, Nuria Albet,, Geeves, M., Barman, T., Barman, Tom, Bloemink, Marieke J, Schmitz, S, Piperio, C., Lionne, C, Albet-Torres, Nuria, Schmitz, Stephan, Bloemink, Marieke J., Golker, K., Bloemink, M., Candau, R., Veigel, C., Herrmann, Christian, Albet-Torres, N., Geeves, Michael A, Mansson, A., Mansson, Alf, Herrmann, C., Månsson, Alf,, Piperio, C, Candau, Robin, Geeves, Michael A., Herrmann, C, Frölander, Kerstin,, Schmitz, S., Candau, R, Piperio, Claudia, Lionne, Corinne, Veigel, Claudia, Bloemink, MJ, Geeves, MA, Frolander, K., Lionne, C., Golker, Kerstin, Frolander, Kerstin, Veigel, C, Golker, Kerstin,, Barman, T   +40 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Upper Limb Orthoses: Integrating Topology Optimization and 3D Printing for Custom Fit and Function

Applied Sciences
Customized wrist splints, particularly for upper extremity orthoses like wrist support braces, are commonly used across numerous clinical scenarios. However, the traditional process for producing personalized wrist splints is largely manual and highly ...
Stefanos Voulgaris, Charoula Kousiatza, George Kazakis, Konstantinos-Iason Ypsilantis, Dimitrios Galanis, Chara Ch. Mitropoulou, Maria Gkara, Stelios K. Georgantzinos, Konstantinos Soultanis, Nikos D. Lagaros   +9 more
doaj   +1 more source