Results 111 to 120 of about 1,750,780 (310)

Measurement for the management of software maintenance [PDF]

open access: yes, 1993
This thesis addresses the problem of bringing maintenance, in a commercial environment, under management control, and also increasing the profile of maintenance in a corporate picture, bringing it onto a par with other components of the business.
Cooper, Simon D., Cooper, S.D
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Maintenance of Application Software-Report

open access: yesIFAC Proceedings Volumes, 1980
Publisher Summary This chapter describes a session on the maintenance of application software. During the life cycle of a software system, maintenance often eats up much more than the initial costs of the system. The session was to discuss this costly and disagreeable problem. It took place in two parts.
openaire   +1 more source

Process Models and Distribution of Work in Offshoring Application Software Development [PDF]

open access: yes
Common process models for the development of application software (AS) are examined as to how well they are suited for offshoring projects. The need for communication and interaction among onsite and offshore project stakeholders is identified as a ...
Kurbel, Karl
core  

Towards an Analytical Approach to Measure Modularity in Software Architecture Design [PDF]

open access: yes, 2015
Modularization is one of the important subjects in the software design area which leads to increasing the level of quality attributes such as maintainability, portability, reusability, interoperability and flexibility.
M. Ghasemi, S. Mehran Sharafi, A. Arman
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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