Results 121 to 130 of about 1,750,780 (310)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Design of a Flow Visualisation Framework

open access: yesComputers, 2015
Research software often consists of individual, isolated prototype applications. Small proof of concept applications are usually enough for demonstrating new algorithms.
Matthew Edmunds   +2 more
doaj   +1 more source

Adverse effect investigation using application software after vaccination against SARS-CoV-2 for healthcare workers. [PDF]

open access: yesJ Infect Chemother, 2022
Yamazaki S   +11 more
europepmc   +1 more source

Assessing security properties of software components : a software engineer's perspective [PDF]

open access: yes, 2006
The paper proposes an assessment scheme for the security properties of software components. The proposed scheme consists of three stages: (i) a system-specific security requirement specification of the enclosing application; (ii) a component-specific ...
Khan, Khaled M., Han, Jun
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Application Software Cybersecurity Scanning [PDF]

open access: yesProceedings of the Annual Hawaii International Conference on System Sciences, 2019
Scanning software applications for cybersecurity vulnerabilities is a crucial step is assessing the overall health of the application, but how can this kind of scan be performed to give development teams the information they need to make informed design decisions? Two pilot cybersecurity scans were conducted in an attempt to answer this question.
openaire   +2 more sources

Support for an integrated approach to program understanding: an application of software visualisation [PDF]

open access: yes, 1998
Program Comprehension is a key factor in providing effective software maintenance and enabling successful evolution of software systems. The objective of this research is to provide a framework and mechanism to facilitate the understanding of large ...
Chan, Pui Shan
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

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