Results 121 to 130 of about 6,204 (225)

Stage‐Specific Metabolic and Proteomic Dynamics Underlying Ripening and Quality Formation in Tropical Evergreen Pomegranate

open access: yeseFood, Volume 7, Issue 4, August 2026.
Integrated multi‐omics reveals that pomegranate ripening between 90 and 130 days drives optimal sugar‐acid balance and pigmentation via coordinated regulation of phenylpropanoid, flavonoid, and carbohydrate metabolism pathways. ABSTRACT Pomegranate fruit development involves coordinated physiological, metabolic, and proteomic changes shaping coloration
Yawen Zhang   +6 more
wiley   +1 more source

Loss of Rab8a‐Dependent Tethering of Lipid Droplets to Mitochondria Contributes to Hypoxia–Reoxygenation Injury

open access: yesMedComm, Volume 7, Issue 8, August 2026.
Rab8a‐dependent tethering of lipid droplets to mitochondria sustains fatty acid oxidation and cardiomyocyte metabolic flexibility under normoxia. During hypoxia/reoxygenation, Rab8a loss and PLIN5‐associated lipophagy uncouple lipid breakdown from mitochondrial utilization, driving lipotoxicity and cell death.
Jialing Tang   +6 more
wiley   +1 more source

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

open access: yesPROTEOMICS, Volume 26, Issue 8, Page 58-68, August 2026.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren   +7 more
wiley   +1 more source

A small‐angle scattering model for broad correlation peaks and small diffuse scattering

open access: yesJournal of Applied Crystallography, Volume 59, Issue 4, Page 1319-1326, August 2026.
For porous and/or bicontinous structures with rather broad correlation peaks and small diffuse scattering, a heuristic theory makes the connection to conditions of material production.Porous and/or bicontinuous structures often display a pronounced correlation peak in their small‐angle scattering that indicates a preferred domain spacing d.
Henrich Frielinghaus
wiley   +1 more source

Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion

open access: yesActa Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow   +4 more
wiley   +1 more source

Pathophysiological and Molecular Features of DXd ADC‐Related Interstitial Pneumonitis in Cynomolgus Monkeys

open access: yesCancer Science, Volume 117, Issue 8, Page 2305-2316, August 2026.
An interstitial lung disease model for DXd antibody‐drug conjugates was established in cynomolgus monkeys by weekly dosing of a non‐targeting DXd ADC. Integrated analysis of bronchoalveolar lavage fluid–derived extracellular vesicle proteomics and lung single‐cell RNA sequencing reveals cell‐type‐resolved molecular features of DXd ADC‐related lung ...
Kazuyoshi Kumagai   +5 more
wiley   +1 more source

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