Results 141 to 150 of about 1,057,597 (306)

Advances of super-resolution fluorescence polarization microscopy and its applications in life sciences. [PDF]

Comput Struct Biotechnol J, 2020
Chen L, Chen X, Yang X, He C, Wang M, Xi P, Gao J.   +6 more
europepmc   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The effects of the New York State Tidal Wetlands Act, moratorium phase

, 1976
iii, 50, 13 p. ; 28 cm. Bibliography.from the abstract, "Marine wetlands play a vital role in the ecology of the estuarine environment. Wetlands support varied populations of specialized plants, mollusks, and crustaceans, as well as offering food and ...
Haje, Roy Louis, Marine Sciences Research Center   +1 more
core  

The Sunway TaihuLight supercomputer: system and applications

, 2016
The Sunway TaihuLight supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the TaihuLight system. In contrast with other existing heterogeneous supercomputers,
Yang, C, Yang, Jinzhe, Wang, Lanning, Qiao, FL, Zhang, Jian, Liao, JF, Qiao, Fangli, Hou, Chaofeng, Yang, Guangwen, Wang, YG, Zhang, CL, Zhao, W, Yang, Chao, Fu, HH, Yang, JZ, Liu, Fangfang, Zhao, Wei, Liao, Junfeng, Song, ZY, Ge, Wei, Zhou, CB, Liu, FF, Zhou, Chunbo, Xue, Wei, Hou, CF, Huang, XM, Wang, LN, Yin, XQ, Xue, W, Ge, W, Zhang, Chenglong, Huang, Xiaomeng, Yin, Xunqiang, Song, Zhenya, Fu, Haohuan, Wang, Yangang, Zhang, J, Yang, GW   +37 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Geostatistics, a colloquium : proceedings of a colloquium on geostatistics held on campus at the University of Kansas, Lawrence on 7-9, June 1970

, 1970
"Sponsored by the Kansas Geological Survey, International Association for Mathematical Geology, and University of Kansas Extension."Although statistics have been used by geologists for many years, only recently has the subject received the attention ...
Merriam, Daniel Francis
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source