Results 161 to 170 of about 1,057,597 (306)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Magnetic Nanoparticles: Synthesis and Applications in Life Sciences. [PDF]

ChemistryOpen
Chand K, Vasquez-Guardado ES.
europepmc   +1 more source

Bioinformatics Applications in Life Sciences and Technologies. [PDF]

Biomed Res Int, 2016
Sousa SA, Leitão JH, Martins RC, Sanches JM, Suri JS, Giorgetti A.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR-Spectroscopy. [PDF]

Angew Chem Int Ed Engl
Schnalzer D, Savic V, Cziegler C, Schnürch M, Mihovilovic MD.   +4 more
europepmc   +1 more source

Cerenkov luminescence imaging: physics principles and potential applications in biomedical sciences. [PDF]

EJNMMI Phys, 2017
Ciarrocchi E, Belcari N.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The applications and problems under the protection and development as a function of human resources management in hotels: The case of Afyonkarahisar

, 2016
Turizm sektörü içerisinde en çok çalışanın istihdam edildiği işletmeler arasında yer alan otel işletmelerinde, müşteri tatmininin sunulan hizmetlerin kalitesine bağlı olması, söz konusu işletmelerde yerine getirilen işlerin çeşitliliği ile ...
Demirdağ, Şerif Ahmet, Pelit, Elbeyi, Gülen, Merve   +2 more
core  

Fast Small-Angle X-Ray Scattering Tensor Tomography: An Outlook into Future Applications in Life Sciences. [PDF]

Small Methods
Appel C, Schmeltz M, Rodriguez-Fernandez I, Anschuetz L, Nielsen LC, Panepucci E, Marijolovic T, Wakonig K, Ivanovic A, Bonnin A, Leonarski F, Wojdyla J, Tomizaki T, Guizar-Sicairos M, Smith K, Beale JH, Glettig W, McAuley KE, Bunk O, Wang M, Liebi M.   +20 more
europepmc   +1 more source

Dynamic light scattering: a practical guide and applications in biomedical sciences. [PDF]

Biophys Rev, 2016
Stetefeld J, McKenna SA, Patel TR.
europepmc   +1 more source