Results 151 to 160 of about 3,693,718 (332)

The Application of Science to Agriculture [PDF]

Nature, 1920
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Advances of super-resolution fluorescence polarization microscopy and its applications in life sciences. [PDF]

Comput Struct Biotechnol J, 2020
Chen L, Chen X, Yang X, He C, Wang M, Xi P, Gao J.   +6 more
europepmc   +1 more source

Rationally designed fluorogenic protease reporter visualizes spatiotemporal dynamics of apoptosis in vivo

Proceedings of the National Academy of Sciences of the United States of America, 2015
Tsz-Leung To, Beverly J Piggott, K. Makhijani, Dan Yu, Y. Jan, X. Shu   +5 more
semanticscholar   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Application of Science to Medicine—The Clinician-Scientist

Annals of the Academy of Medicine, Singapore, 2013
Zhongwei, Huang, Eu Leong, Yong
openaire   +2 more sources

NISS WebSwap: A Web Service for Data Swapping [PDF]

Data swapping is a statistical disclosure limitation practice that alters records in the data to be released by switching values of attributes across pairs of records in a fraction of the original data.
Alan F. Karr, Ashish Sanil, Shanti Gomatam   +2 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Carbon Cycle Science Data and Services at the Goddard Earth Sciences Data Information and Services Center (GES DISC) [PDF]

The Goddard Earth Sciences Data Information and Services Center (GES DISC) archives and distributes a number of observational and model carbon cycle science data sets.
Adams, Jennifer, Hearty, Thomas, Huwe, Paul, Meyer, David, Ostrenga, Dana, Savtchenko, Andrey, Wei, Jennifer   +6 more
core   +1 more source