Results 121 to 130 of about 5,179,819 (323)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Regime Switching GARCH : An Application to Dowjones Index Return [PDF]

open access: yes, 2007
Since firstly proposed by Engle (1982) and Bollerslev (1986), ARCH-GARCH models have been used to describe volatility behaviors of time series, especially in stock market analysis.
Hadiyat, Mochammad Arbi   +2 more
core  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Finite element analysis of non-isothermal multiphase porous media in dynamics [PDF]

open access: yes, 2015
This work presents a mathematical and a numerical model for the analysis of the thermo-hydro-mechanical (THM) behavior of multiphase deformable porous materials in dynamics.
Sanavia, Lorenzo, Toan Duc, Cao
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Group Physical Activity and Behavioral Practices in Adolescents with Autism: A Case Series on Integrated Educational Interventions

open access: yesEducation Sciences
Research on physical activity (PA) interventions for individuals with autism spectrum disorder (ASD) has shown benefits in various domains, yet questions remain about how to implement such interventions in adolescents effectively.
Marco Esposito   +7 more
doaj   +1 more source

Feedback and the Use of Current Information: The Use of General Linear Policy Rules in Rational Expectations Models [PDF]

open access: yes
The behavior of several stochastic dynamic rational expectations models is studied when policy behavior can be described by a linear rule. Four policy components are distinguished: a current response component, a feedback component, an open-loop ...
Willem H. Buiter
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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