Results 131 to 140 of about 30,599,211 (279)

A functional-analytic model of analogy: a relational frame analysis.

, 2002
The aim of this study was to explore a behavior-analytic model of analogical reasoning, defined as the discrimination of formal similarity via equivalence-equivalence responding.
Roche, Bryan, Smeets, Paul M, Stewart, Ian, Barnes-Holmes, Dermot   +3 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Large time behavior of solutions to a moving-interface problem modeling concrete carbonation

, 2010
We study the large time behavior of the weak solutions to a one-phase moving sharp-interface PDE system describing the aggressive penetration of gaseous carbon dioxide in unsaturated concrete.
Aiki, Toyohiko,, Muntean, Adrian,, Aiki, T., Muntean, A.   +3 more
core   +1 more source

The aim, progress, and evolution of behavior analysis

, 1992
Skinner's contributions to and aim and progress and evolution of behavior analysisDiscusses Skinner's 3 major contributions to behavior analysis: prediction and control (1931), the 3-term contingency (1938), and radical behaviorism (1945). Skinner's most

core   +1 more source

Teaching Communication and Functional Life Skills in Children Diagnosed with Autism Spectrum Disorder

Behavioral Sciences
Children with autism spectrum disorder (ASD) commonly show difficulty in communication and daily functional skills. The use of scripts may help establish these repertoires.
Juliana Ribeiro Rabelo Costa, Daniel Carvalho de Matos   +1 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Defusion: A Behavior-analytic Strategy for Addressing Private Events

, 2011
Applied behavior analysts encounter situations in which private events hinder client progress, and additional techniques to address these issues are needed.
Snyder, Katherine, Twohig, Michael P., Joseph Lambert, Katie Snyder, Lambert, Joseph, Michael P. Twohig   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The Expression of equivalence classes influenced by distractors during DMTS test trials [PDF]

, 2013
When training and testing are conducted with trials presented in a delayed matching to sample (DMTS) format, mediating behaviors may occur during the delay that separates sample offset and comparison onset.
Vie, Aleksander, Arntzen, Erik
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source