Results 151 to 160 of about 1,594,306 (217)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Upholding Anti-ableism in Applied Behavior Analysis: A Strengths-Based Approach to Goal Writing and Direct Service. [PDF]

Behav Anal Pract
Malone EJ, White BL, Aavatsmark FW, Contreras BP, Tuck KN.   +4 more
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Mapping the Evidence on Compassion Skills in Applied Behavior Analysis: Protocol for Scoping Review. [PDF]

JMIR Res Protoc
Nunes Longhi Aleixo D, Junior Martins de Souza D, Regina Pedroso Vilela Torres de Carvalho S, Regina Furlani M, Canato Martins C, Santos ERD, Souza Menezes JD, Querino da Silva M, Maria Maciel Lopes S, Sanches Rodrigues M, Almeida de Arnaldo Silva Rodriguez Castro N, Landim Gonçalves Cristóvão H, Ittavo Lamana Faria J, Maria Sabadoto Brienze V, Regina de Abreu Lima A, Silva Fucuta PD, Cristina Móz Vaz Oliani D, Aparecida Micelli Domingos N, Cristina Oliveira Santos Miyazaki M, Maria de Araújo Filho G, César André J.   +20 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Breaking Barriers with Humor and Heart: Dr. Elizabeth Hughes Fong's Contributions to the Culturally Sensitive Practice of Applied Behavior Analysis. [PDF]

Behav Anal Pract
Catagnus RM, Gharapetian L, Najdowski A, Syed N, Tarbox J.   +4 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source