Results 61 to 70 of about 1,400,328 (262)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Le développement durable : enfant prodigue ou rejeton matriphage de la protection de la nature ? [PDF]

open access: yesLes Ateliers de l’Ethique, 2006
Although there exists a strong uncertainty surrounding the evaluation of the decline of biodiversity, and a larger uncertainty still regarding projections of the decline to come, there is no controversy on the fact that the current rate of extinction is ...
Virginie Maris
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Implementing the Precautionary Principle through Stakeholder Engagement for Product and Service Development [PDF]

open access: yesLes Ateliers de l’Ethique, 2007
The precautionary principle is a sustainable development principle that attempts to articulate an ethic in decision making since it deals with the notion of uncertainty of harm.
Pierre de Coninck, Carmen Cucuzella
doaj  

È la pratica che distingue una professione o una norma che ne delinea i confini?

open access: yesRi-vista: Ricerche per la Progettazione del Paesaggio, 2015
Ethics applied to environment and landscape is a topic that has a wide range of approaches. The shared acknowledgement of environment as a value, is not enough to guarantee clear indications about how to inhabit it.
Giuseppe De Luca
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Etica applicata, ambiente, paesaggio

open access: yesRi-vista: Ricerche per la Progettazione del Paesaggio, 2015
Ethics applied to environment and landscape is a topic that has a wide range of approaches. The shared acknowledgement of environment as a value, is not enough to guarantee clear indications about how to inhabit it.
Simone Morandini
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

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