Results 51 to 60 of about 13,950,141 (192)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Temporal Convolutional Neural Network Analysis of Magnetocardiography Signals for Detection of Pulmonary Hypertension

Bioengineering
Non-invasive methods used for PH detection in clinical practice have several limitations. The combination of high spatiotemporal sensitivity magnetocardiography (MCG) and artificial intelligence algorithms may offer an accurate approach for PH detection.
Yuankun Qi, Kai Ma, Xiaole Han, Dong Xu, Xu Zhang, Min Xiang   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Development and characterization of Nb3Sn/Al2O3 superconducting multilayers for particle accelerators

Scientific Reports, 2021
Superconducting radio-frequency (SRF) resonator cavities provide extremely high quality factors > 1010 at 1–2 GHz and 2 K in large linear accelerators of high-energy particles.
Chris Sundahl, Junki Makita, Paul B. Welander, Yi-Feng Su, Fumitake Kametani, Lin Xie, Huimin Zhang, Lian Li, Alex Gurevich, Chang-Beom Eom   +9 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Magnetism and local symmetry breaking in a Mott insulator with strong spin orbit interactions

Nature Communications, 2017
Local probing into the microscopic degrees of freedom is highly desired to understand emergent exotic quantum phases. Here, the authors report a canted ferromagnetic phase preceded by local point symmetry breaking at low temperature in Ba2NaOsO6 ...
L. Lu, M. Song, W. Liu, A. P. Reyes, P. Kuhns, H. O. Lee, I. R. Fisher, V. F. Mitrović   +7 more
doaj   +1 more source

Phase diagram of YbZnGaO4 in applied magnetic field

npj Quantum Materials, 2021
Recently, Yb-based triangular-lattice antiferromagnets have garnered significant interest as possible quantum spin-liquid candidates. One example is YbMgGaO4, which showed many promising spin-liquid features, but also possesses a high degree of disorder ...
William Steinhardt, P. A. Maksimov, Sachith Dissanayake, Zhenzhong Shi, Nicholas P. Butch, David Graf, Andrey Podlesnyak, Yaohua Liu, Yang Zhao, Guangyong Xu, Jeffrey W. Lynn, Casey Marjerrison, A. L. Chernyshev, Sara Haravifard   +13 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spectroscopic temperature measurement in a applied field MPD

, 2007
In this paper the temperature of the plasma inside an MPD thruster has been measured with and without applied magnetic field using spectroscopic measurement.
Coletti, M., Paccani, G., Ciampone, S., Mazzitelli, G.   +3 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source