Results 81 to 90 of about 585,125 (273)

Eye-Safe Solid-State Quasi-CW Raman Laser with Millisecond Pulse Duration

, 2012
We demonstrate the first quasi-CW (ms-long pulses, pump duty cycle of 10%) end-diode pumped solid state laser generating eye-safe radiation via intracavity Raman conversion. The output power at the first Stokes wavelength (1524 nm) was 250 mW.
Agnesi, Anton A. Kananovich, Apanasevich, Apanasevich, Bermudez, Boyd, Cerný, Chen, Dekker, Dekker, Demidovich, Di Lieto, Dmitriy H. Zusin, Fan, Grabchikov, Grabtchikov, Grasjuk, Innocenzi, Kaminskii, Kananovich, Kananovich, Lee, Lee, Lisinetskii, Ogilvy, Omatsu, Pask, Pask, Pask, Pavel, Pavel A. Apanasevich, Sato, Tidwell, Valentin A. Orlovich, Vladimir I. Dashkevich, Weber, Yao, Zagumennyi   +37 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Time-domain adjoint optimization for metalens design toward enhanced broadband efficiency and uniformity

iScience
Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park, Haejun Chung, Kyung-Young Jung   +2 more
doaj   +1 more source

An omnidirectional retroreflector based on the transmutation of dielectric singularities

, 2009
In the field of transformation optics, metamaterials mimic the effect of coordinate transformations on electromagnetic waves, creating the illusion that the waves are propagating through a virtual space.
Leonhardt, Ulf, Ma, Yun Gui, Ong, C. K., Tyc, Tomas   +3 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Beam shaping elements for single photon sources based on 3D printed micro-optics [PDF]

EPJ Web of Conferences
Multiple researchers have explored the use of 3D printed micro-optical components as interfaces to quantum point emitters by considering different designs and configurations. Typically, these designs involve parametric structures optimized in combination
Jimenez Carlos, Toulouse Andrea, Herkommer Alois   +2 more
doaj   +1 more source

Ramsauer approach for light scattering on non-absorbing spherical particles and application to the Henyey-Greenstein phase function

, 2012
We present a new method to study light scattering on non-absorbing spherical particles. This method is based on the Ramsauer approach, a model known in atomic an nuclear physics. Its main advantage is its intuitive understanding of the underlying physics
Louedec, K., Urban, M.
core   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Optical Design of the Atacama Cosmology Telescope and the Millimeter Bolometric Array Camera

, 2007
The Atacama Cosmology Telescope is a 6-meter telescope designed to map the Cosmic Microwave Background simultaneously at 145 GHz, 215 GHz, and 280 GHz with arcminute resolution.
Benford, Bennett, Brown, Carlstrom, Devlin, Dicker, Dragone, Dragone, Fowler, Griffin, Hernández-Monteagudo, Huffenberger, Jones, Kuo, Lamb, Lau, Lau, Leitch, Marriage, O'Dwyer, Parshin, Readhead, Rusch, Spergel, Tanaka   +24 more
core   +3 more sources