Results 81 to 90 of about 584,758 (318)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Eye-Safe Solid-State Quasi-CW Raman Laser with Millisecond Pulse Duration

, 2012
We demonstrate the first quasi-CW (ms-long pulses, pump duty cycle of 10%) end-diode pumped solid state laser generating eye-safe radiation via intracavity Raman conversion. The output power at the first Stokes wavelength (1524 nm) was 250 mW.
Agnesi, Anton A. Kananovich, Apanasevich, Apanasevich, Bermudez, Boyd, Cerný, Chen, Dekker, Dekker, Demidovich, Di Lieto, Dmitriy H. Zusin, Fan, Grabchikov, Grabtchikov, Grasjuk, Innocenzi, Kaminskii, Kananovich, Kananovich, Lee, Lee, Lisinetskii, Ogilvy, Omatsu, Pask, Pask, Pask, Pavel, Pavel A. Apanasevich, Sato, Tidwell, Valentin A. Orlovich, Vladimir I. Dashkevich, Weber, Yao, Zagumennyi   +37 more
core   +1 more source

Time-domain adjoint optimization for metalens design toward enhanced broadband efficiency and uniformity

iScience
Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park, Haejun Chung, Kyung-Young Jung   +2 more
doaj   +1 more source

Beam shaping elements for single photon sources based on 3D printed micro-optics [PDF]

EPJ Web of Conferences
Multiple researchers have explored the use of 3D printed micro-optical components as interfaces to quantum point emitters by considering different designs and configurations. Typically, these designs involve parametric structures optimized in combination
Jimenez Carlos, Toulouse Andrea, Herkommer Alois   +2 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Implementation of projective measurements with linear optics and continuous photon counting

, 2004
We investigate the possibility of implementing a given projection measurement using linear optics and arbitrarily fast feedforward based on the continuous detection of photons.
A. S. Holevo, A. S. Holevo, A. S. Holevo, C. W. Gardiner, C. W. Helstrom, J. Calsamiglia, K. Yamazaki, M. D. Srinivas, M. D. Srinivas, Masahide Sasaki, Masahiro Takeoka, Norbert Lütkenhaus, Peter van Loock   +12 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Quantum coherence generated by interference-induced state selectiveness

, 2001
The relations between quantum coherence and quantum interference are discussed. A general method for generation of quantum coherence through interference-induced state selection is introduced and then applied to `simple' atomic systems under two-photon ...
BARDOU F., CARREAU J. C., CARREAU J. C., JEAN CLAUDE GARREAU, WANG F., WILKOWSKI D.   +5 more
core   +1 more source

Femto-Laser Processed Metasurface With Fano Response: Applications to a High Performance Refractometric Sensor

Photonic Sensors
The practical development of compact modern nanophotonic devices relies on the availability of fast and low-cost fabrication techniques applicable to a wide variety of materials and designs.
Mahmoud H. Elshorbagy, Alejandro San-Blas, Luis Miguel Sanchez-Brea, Santiago M. Olaizola, Jesús del Hoyo, Angela Soria-Garcia, Joaquin Andres-Porras, Verónica Pastor-Villarrubia, Javier Alda   +8 more
doaj   +1 more source