Results 91 to 100 of about 169,669 (288)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Time-domain adjoint optimization for metalens design toward enhanced broadband efficiency and uniformity

iScience
Summary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park, Haejun Chung, Kyung-Young Jung   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Applications of Lasers for Sensing and Free Space Communications: introduction to the feature issue

, 2023
ALS1ALS4This feature issue highlights the latest developments in laser-based sensing and free space communications. In total, 15 papers were published in Applied Optics, including an invited review paper that celebrates the legacy of David L.
Watson, Edward A., Mark F. Spencer, Spencer, Mark F., Fuerbach, Alex, Alex Fuerbach, Bose-Pillai, Santasri, Miranda van Iersel, Riviere, Nicolas, Edward A. Watson, Toselli, Italo, Iersel, Miranda van, Nicolas Riviere, Santasri Bose-Pillai, Italo Toselli   +13 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Adaptive multilayer optics for extreme ultraviolet wavelengths [PDF]

, 2015
In this thesis we describe the development of a new class of optical components to enhance the imaging performance by enabling adaptations of the optics.
Bayraktar, Muharrem, Bayraktar, Muharrem; id_orcid   +1 more
core   +1 more source

Optical performance simulation of free-form optics for an eye implant based on a measurement data enhanced model

, 2022
S.6671-6679This paper describes the application of a modeling approach for precise optical performance prediction of free-form optics-based subsystems on a demonstration model of an eye implant.
Beckert, E., Sieber, I., Yi, A.Y., Gengenbach, U., Steinkopf, R., Li, L.   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Femto-Laser Processed Metasurface With Fano Response: Applications to a High Performance Refractometric Sensor

Photonic Sensors
The practical development of compact modern nanophotonic devices relies on the availability of fast and low-cost fabrication techniques applicable to a wide variety of materials and designs.
Mahmoud H. Elshorbagy, Alejandro San-Blas, Luis Miguel Sanchez-Brea, Santiago M. Olaizola, Jesús del Hoyo, Angela Soria-Garcia, Joaquin Andres-Porras, Verónica Pastor-Villarrubia, Javier Alda   +8 more
doaj   +1 more source