Results 51 to 60 of about 2,669,677 (322)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Materials Science at Swiss Universities of Applied Sciences

open access: yesCHIMIA, 2019
In the Swiss Universities of Applied Sciences, several research institutes are involved in Materials Science, with different approaches and applications fields. A few examples of recent projects from different groups of the University of Applied Sciences and Arts Western Switzerland (HES-SO), the Zurich University of Applied Sciences (ZHAW) and the ...
Pierre Brodard   +14 more
openaire   +5 more sources

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

PAT at the Universities of Applied Sciences

open access: yesCHIMIA, 2015
An overview of activities in the field of Process Analytical Technologies (PAT) at the Universities of Applied Sciences in Switzerland is presented
Wolfgang Riedl   +8 more
openaire   +5 more sources

Introduction to Applied Data Science [PDF]

open access: yes, 2019
What is data science? Attempts to define it can be made in one (prolonged) sentence, while it may take a whole book to demonstrate the meaning of this definition. This book introduces data science in an applied setting, by first giving a coherent overview of the background in Part I, and then presenting the nuts and bolts of the discipline by means of ...
Stadelmann, Thilo   +2 more
openaire   +1 more source

Editorial (a preface to a Special Issue of journal Applied Sciences on "Guided-Wave Optics") [PDF]

open access: yesarXiv, 2017
This is a preface introducing a Special Issue on the topic of "Guided-Wave Optics" published by Applied Sciences. The Special Issue is a collection of 20 original and review articles dealing with various fundamental and applied aspects of the topic.
arxiv  

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

open access: yesFEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan   +10 more
wiley   +1 more source

First principles phonon calculations in materials science [PDF]

open access: yesarXiv, 2015
Phonon plays essential roles in dynamical behaviors and thermal properties, which are central topics in fundamental issues of materials science. The importance of first principles phonon calculations cannot be overly emphasized. Phonopy is an open source code for such calculations launched by the present authors, which has been world-widely used.
arxiv  

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