Results 81 to 90 of about 16,264,514 (388)

Drug nanocrystals: Surface engineering and its applications in targeted delivery

iScience
Summary: Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug ...
Phattalapol Lhaglham, Luksika Jiramonai, Yaru Jia, Baoying Huang, Yuanyu Huang, Xueyun Gao, Jinchao Zhang, Xing-Jie Liang, Mengliang Zhu   +8 more
doaj   +1 more source

Forecasting and Forecast Combination in Airline Revenue Management Applications [PDF]

, 2008
Predicting a variable for a future point in time helps planning for unknown future situations and is common practice in many areas such as economics, finance, manufacturing, weather and natural sciences. This paper investigates and compares approaches
Gabrys, Bogdan, Lemke, Christiane
core  

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

“PyTDL”: A versatile temporal difference learning algorithm to simulate behavior process of decision making and cognitive learning

iScience
Summary: Humans and animals excel at learning complex tasks through reward-based feedback, dynamically adjusting value expectations and choices based on past experiences to optimize outcomes. However, understanding the hidden cognitive components driving
Qiyun Wu, Xiaodan Yang, Kaishu Wang, Min Zhu, Jiejunyi Liang, Yunyun Han   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Following the robot’s lead: Predicting human and robot movement from EEG in a motor learning HRI task

iScience
Summary: A large proportion of human behavior is organized in time in the form of sensorimotor sequences. Learning new behavioral sequences recruits cognitive functions with their neural underpinnings.
Tanaya Chatterjee, Adrien Guzzo, Alejandro Tlaie, Ahmad Kaddour, Charalambos Papaxanthis, Jeremie Gaveau, Peter Ford Dominey   +6 more
doaj   +1 more source

EVALUATION REPORT OF LAUREA UNIVERSITY OF APPLIED SCIENCES 2010 [PDF]

, 2011
In this report, the evaluation board considers international level RDI and a high quality research culture as a central means for attaining Laurea’s vision.
Löytönen, Markku, Schwab-Matkovits, Ingrid, Spaapen, Jack, Varmola, Tapio   +3 more
core  

Statistical mixing and aggregation in Feller diffusion

, 2009
We consider Feller mean-reverting square-root diffusion, which has been applied to model a wide variety of processes with linearly state-dependent diffusion, such as stochastic volatility and interest rates in finance, and neuronal and populations ...
, Anteneodo C Malmgren R D Chialvo D R, Bouchaud J P, C Anteneodo, Cassidy D L, Cooper R B, Cortines A A G, Duarte Queirós S M, Embrechts P, Kaizoji T Sornette D, Kotz S, Maguire B A, Morrison D F, Osorio R, Queirós S M D, Reynolds A M, S M Duarte Queirós, Sornette D   +17 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Advances of 3D bioprinting technology for periodontal tissue regeneration

iScience
Summary: 3D bioprinting technology for periodontal tissue regeneration is an advanced manufacturing technique that utilizes three-dimensional (3D) printing principles to fabricate intricate, viable structures that are specifically devised to meet with ...
Huanhuan Chen, Yu Wang, Yue Lai, Chenda Meng, Xiner Ning, Tianmin Xu, Guangying Song, Yunfan Zhang, Yifan Lin, Bing Han   +9 more
doaj   +1 more source