Results 81 to 90 of about 4,649,929 (326)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Dimensionless fluctuations balance applied to statistics and quantum physics

Scientific Reports
This work presents a new method called Dimensionless Fluctuation Balance (DFB), which makes it possible to obtain distributions as solutions of Partial Differential Equations (PDEs).
Marceliano Oliveira, George Valadares, Francisco Rodrigues, Márcio Freire   +3 more
doaj   +1 more source

Non-parametric indices of dependence between components for inhomogeneous multivariate random measures and marked sets

, 2016
We propose new summary statistics to quantify the association between the components in coverage-reweighted moment stationary multivariate random sets and measures.
van Lieshout, M. N. M.
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Applied Statistics [PDF]

Journal of the Royal Statistical Society Series C: Applied Statistics, 2020
N. Friel, P. W. F. Smith, A. Canale, N. Demiris, Y. Fan, C. Gaetan, X. Huang, M. Iannario, T. Jaki, I. H. Jermyn, K. Kalogeropoulos, P. Latouche, S. Liverani, G. Marra, J. Mateu, R. X. De Menezes, I. Ntzoufras, D. Oberski, T. Papamarkou, D. Prangle, R. Radice, A. Sykulski   +21 more
openaire   +1 more source

Moderate deviations for a nonparametric estimator of sample coverage

, 2013
In this paper, we consider moderate deviations for Good's coverage estimator. The moderate deviation principle and the self-normalized moderate deviation principle for Good's coverage estimator are established.
Gao, Fuqing
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Statistical Literacy Among Applied Linguists and Second Language Acquisition Researchers

, 2014
The importance of statistical knowledge in applied linguistics and second language acquisition (SLA) research has been emphasized in recent publications.
Aiken, Aiken, Aiken, Alder, Bailey, Barkhuizen, Beyth-Marom, Brown, Brown, Brown, Chapelle, Cumming, Cunnings, Curtis, Ellis, Ellis, Fidler, Field, Finney, Gass, Henson, Larson-Hall, Larson-Hall, Lazaraton, Lazaraton, Lazaraton, Leech, Loewen, Norris, Plonsky, Plonsky, Porte, Richards, Zimiles   +33 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source