Results 141 to 150 of about 130,322 (292)

Multi-period appointment planning and scheduling in healthcare

, 2020
Randevu planlaması ve çizelgelemesi, hastalara verilen hizmetin kalitesinde ve önemli kaynakların verimli kullanılabilmesinde çok büyük rol oynar. Bu çalışmada, bir ayakta tedavi polikliniğinde, birden çok dönem için planlama ve çizelgeleme kararlarını beraber ele alan, iki aşamalı stokastik programlama modeli kullanılmıştır.
openaire   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Hepatitis C Virus Treatment Outcomes Using a Family Medicine Interdisciplinary Team. [PDF]

Ann Fam Med
Hull M.
europepmc   +1 more source

Diffusion‐MRI‐Based Estimation of Cortical Architecture via Machine Learning (DECAM) in Primate Brains

Advanced Science, EarlyView.
We present Diffusion‐MRI‐based Estimation of Cortical Architecture via Machine Learning (DECAM), a deep‐learning framework for estimating primate brain cortical architecture optimized with best response constraint and cortical label vectors. Trained using macaque brain high‐resolution multi‐shell dMRI and histology data, DECAM generates high‐fidelity ...
Tianjia Zhu, Minhui Ouyang, Shufang Tan, Jianlin Guo, Ziqin Zhang, Xuan Liu, Risheng Liu, Hao Huang   +7 more
wiley   +1 more source

Deriving Optimal Treatment Timing for Adaptive Therapy: Matching the Model to the Tumor Dynamics. [PDF]

Bull Math Biol
Gallagher K, Strobl MAR, Anderson ARA, Maini PK.   +3 more
europepmc   +1 more source

Port Chester-Rye Union Free School District and Port Chester-Rye School Unit, CSEA, Local 1000, AFSCME, AFL-CIO, Westchester County Local 860 (2005) [PDF]

, 2005

core   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Attitudes to vaccine co-administration in adults: A scoping review of qualitative evidence. [PDF]

Hum Vaccin Immunother
Lazarus R, Williams V, Cochrane H, Rees S, Seale H.   +4 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Perspectives of Community Health Center Employees on Public Bus Transportation in Rural Hawai'i County. [PDF]

Int J Environ Res Public Health
Keliikoa LB, Hartz C, Pontalti A, Reelitz K, Hansen Smith H, Otsuka K, Ching LK, McGurk MD.   +7 more
europepmc   +1 more source