Results 231 to 240 of about 141,145 (350)

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Pregnancy and Residency: Program and ACGME Recommendations From the Council of Review Committee Residents Pregnancy in Training Task Force. [PDF]

J Grad Med Educ
Caldwell KE, Marsh KM, Finke A, Schmitt E, Colucci L, Erickson T, Miller A, Salah H, Graese P, Ranson S, Daniels GM.   +10 more
europepmc   +1 more source

Early Detection and Inhibition of Post‐Surgical Cancer Recurrence by Synthetic Extracellular Vesicles

Advanced Science, EarlyView.
An implantable hydrogel is designed to hold gene transfection agents engineered to turn early recurrent tumor cells into generators of synthetic EVs. These synthetic EVs can express engineered miR‐26a (E‐miR‐26a) for highly sensitive detection and PD‐1 (a PD‐L1‐blocking agent) for therapeutic intervention, thereby enabling early detection and ...
Junli Zhang, Wenjia Chang, Ruolin Hu, Peiyan Su, Qin Zhou, Yanan Li, Zhenzhong Zhang, Kaixiang Zhang   +7 more
wiley   +1 more source

Visit-level prediction of missed HIV appointments using machine learning and transformer-based models in Uganda. [PDF]

BMC Med Inform Decis Mak
Mirugwe A, Ssevvume S, Fitzmaurice AG, Mpango J, Namale A, Akello E, Katongole P, Muhumuza S, Mayanja N, Mbaka P, Sande E, Musenge K.   +11 more
europepmc   +1 more source

Northville Central School District and Northville Teachers Association (2000) [PDF]

, 2000

core   +1 more source

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Barriers to Wellness Among General Surgery Residents During the COVID-19 Pandemic: Qualitative Analysis of Survey Responses. [PDF]

JMIR Perioper Med
Bilgen I, Castelo M, Reel E, Nguyen MA, Greene B, Lu J, Brar S, Cil T.   +7 more
europepmc   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

Sociodemographic determinants of appointment no-show in primary care: a cross-sectional study in Renca Commune, Chile (2022-2023). [PDF]

BMC Prim Care
Escobar-San Martín P, Droguett Droguett N, Sabando Franulic V.   +2 more
europepmc   +1 more source

Liverpool Central School District and United Liverpool Faculty Association (ULFA), Office Personnel Association of Liverpool Schools (2003) [PDF]

, 2003

core   +1 more source