Results 221 to 230 of about 141,145 (350)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Patient and Physician Perspectives on the Management of Diabetic Macular Edema. [PDF]

Ophthalmol Ther
Warren B, Donohoe M, Sivaprasad S, Wykoff CC.   +3 more
europepmc   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Co-Designing Lung Cancer Rehabilitation Services for People Treated With Immunotherapy. [PDF]

Health Expect
Edbrooke L, Pearson E, Granger CL, Denehy L.   +3 more
europepmc   +1 more source

Seattle Community College District VI Board of Trustees and Seattle Community Colleges Federation of Teachers, Washington Federation of Teachers (WFT), American Federation of Teachers (AFT), AFL-CIO, Local 1789 (2003) [PDF]

, 2003

core   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Baby Fever: Examining Parental Leave Policies and Pregnancy Accommodations on Emergency Medicine (EM) Residency and Graduate Medical Education (GME) Websites. [PDF]

Cureus
Hoag E, Haussner D, Melisiotis D, Morrone C, Bierowski A.   +4 more
europepmc   +1 more source

Jamestown City School District and Jamestown Teachers Association (JTA) (2000) [PDF]

, 2000

core   +1 more source

A Nanobody‐LNP Platform for Targeting and Relicensing Dendritic Cells for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
Plastin‐2 (PLS2) is identified as a dual‐function receptor on DCs that mediates both nanoparticle uptake and immunomodulation. A nanobody‐LNP platform is engineered to integrate antigen delivery with relicensing DCs. The therapeutic strategy elicits potent anti‐tumor T cell responses and leads to significant inhibition of established tumors in vivo ...
Shugang Qin, Zhiying Huang, Hai Huang, Yupei Zhang, Yuting Chen, Xi He, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Xiangrong Song   +9 more
wiley   +1 more source

Patient-, care partner-, and clinician-proposed solutions to address the time toxicity of cancer care. [PDF]

Support Care Cancer
Johnson WV, Valisekka SS, Ogunleye OO, Stevens SX, George M, Breininger A, Kyle MA, Booth CM, Hanna TP, Vogel RI, Parsons HM, Blaes AH, Gupta A.   +12 more
europepmc   +1 more source