Results 91 to 100 of about 392,567 (314)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Weight discrepancy and body appreciation of Zimbabwean women in Zimbabwe and Britain
, 2012 Few studies have investigated a cultural group's corporeal experiences in both its country of origin and a host, Western country using the same methodology.
Swami, V., Tovee, M.J., Mada, R.
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Equilibrium exchange rates in the transition: The tradable price-based real appreciation and estimation uncertainty [PDF]
This paper sets out to estimate equilibrium real exchange rates for the Czech Republic, Hungary, Poland, Slovakia and Slovenia. A theoretical model is developed that provides an explanation for the appreciation of the real exchange rate based on tradable
Lommatzsch, Kirsten, Égert, Balázs
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Yoga in the Evangelical Lutheran Church in Denmark
TemenosYoga has become increasingly popular in Denmark, much as in other European countries. However, its integration into Danish society often involves secularization or recontextualization to fit local cultural and religious frameworks. This article examines
Marianne Qvortrup Fibiger
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Arts Appreciation Club of Rock Hill Records - Accession 1349 - M723 (779)
, 2020 The Arts Appreciation Club of Rock Hill Records consists of records produced by the club and includes meeting minutes, club member directories, club rules, calendar of events, advertisements, correspondence, handbooks, financial records, programs of ...
Woman\u27s Club of Rock Hill +1 more
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, 2015 Neuroimaging studies of aesthetic appreciation have shown that activity in the lateral occipital area (LO)—a key node in the object recognition pathway—is modulated by the extent to which visual artworks are liked or found beautiful.
Vecchi, T. +6 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source