Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Pastor's Appreciation Luncheon
Pastor's Appreciation Luncheon, held in WMU Hall, October ...
Mohler, R. Albert
core
DISGUST AS A CONCEPTUAL FOUNDATION FOR ART APPRECIATION IN THE COMMUNITY COLLEGE: A THOUGHT EXPERIMENT IN PRACTICE [PDF]
Reflecting on the history of art appreciation and viewing its current context within a community college, as a general education course that largely perpetuates cultural miseducation (Martin 2011) through preservation of the Western canon, this ...
Johnston, Catherine
core
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Risky neighborhoods? House appreciation in underserved areas [PDF]
This research project will investigate house price appreciation trends in traditionally underserved areas. The primary goal is to develop and test a methodology to determine what part of a home (appreciation)is due to structural and neighborhood effects,
Ayse Can +2 more
core
Critical Discourse Analysis on “We are the World 25 for Haiti” Song Lyrics
This research aims in analyzing a song entitled “We are the World 25 for Haiti”. This song was first introduced by Michael Jackson in 1985 named “We are the World 1985” when he made collaboration with other musicians for USA for Africa (United Support of
Herman Herman, Dumaris Silalahi
doaj +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Black-White Appreciation of Owner Occupied Homes in Upper Income Suburban Integrated Communities: The Cases of Maplewood and Montclair, New Jersey [PDF]
The purpose of this paper is to examine black-white differences in housing appreciation in northern New Jersey, with particular emphasis on the communities of Montclair and Maplewood in the 1970 to 2000 period. We find that home appreciation at the block
Richard Schwester, Douglas Coate
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source

