Results 91 to 100 of about 266,328 (249)

Appropriateness of Brain Magnetic Resonance Imaging (MRI) Prescriptions and Imposed Financial Burden: Evidence from Iran

Journal of Evidence Based Health Policy, Management & Economics, 2022
Background: The use of advanced and expensive technologies requires financial, human and capital resources. Brain Magnetic Resonance Imaging (MRI) has high contrast sensitivity for visualizing differences among the tissues. Unnecessary diagnostic imaging
Mohammadreza Kalantarhormozi, Ahmad Yazdanpanah, Mohammadreza Yazdankhahfard, Batool Amiri, Reza Nemati, Milad Sohrabi Shekafti, Hedayat Salari, Atefe Esfandiari   +7 more
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Survey on appropriateness of use of nimesulide in nine European countries

, 2015
Silvia Franchi,1 Franca Heiman,2 Elena Visentin,2 Paola Sacerdote,1 1Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, Italy; 2Cegedim Strategic Data Medical Research Srl, Milan, Italy Background ...
Heiman F, Visentin E, Sacerdote P, Franchi S   +3 more
core  

Evidence-Based Clinical Recommendations on the Appropriateness of Prescriptions and Diagnostic Tests in Paediatric Allergology: Focus on IgE-Mediated and Non-IgE Mediated Food Allergy, Eosinophilic Gastrointestinal Disease, Urticaria, Angioedema and Atopic Dermatitis

Children
Background: Appropriate diagnostic testing is essential to quality pediatric allergy care, affecting diagnostic accuracy, treatment decisions, resource use, and patient outcomes.
Valentina Fainardi, Matteo Riccò, Rachele Antignani, Simona Bellodi, Mauro Calvani, Fabio Cardinale, Elena Chiappini, Maria Angiola Crivellaro, Daniela Cunico, Massimiliano Esposito, Antonella Giudice, Roberto Grandinetti, Amelia Licari, Michele Miraglia Del Giudice, Maria Marsella, Alberto Martelli, Anna Montanari, Iria Neri, Rita Nocerino, Elisabetta Palazzolo, Diego Peroni, Cristina Piersantelli, Giuseppe Pingitore, Giuseppe Squazzini, Mariangela Tosca, Carlo Caffarelli, Susanna Esposito   +26 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Optimal appropriateness measurement

appropriateness measurement, item response theory, optimal appropriateness measurement, Neyman-Pearson lemma, psychological tests,
Fritz Drasgow, Michael Levine
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Appropriateness of maternal referral system and its associated factors in Eastern Ethiopia: a facility-based cross-sectional study

Frontiers in Global Women's Health
BackgroundGiven majority of obstetric complications are often unpredictable, an appropriate maternal referral system is crucial to manage life-threatening obstetric complications and prevent maternal deaths. Although Ethiopia is one of the countries with
Betelhem Mengist Sharew, Agumasie Semahegn, Agumasie Semahegn, Agumasie Semahegn, Shegaye Yibabie Damtie, Nigus Kassie Worku, Abera Kenay Tura, Abera Kenay Tura, Abera Kenay Tura   +8 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Outpatient Antibiotic Prescribing Patterns in Children among Primary Healthcare Institutions in China: A Nationwide Retrospective Study, 2017–2019

Antibiotics
There is scarce evidence to demonstrate the pattern of antibiotic use in children in China. We aimed to describe antibiotic prescribing practices among children in primary healthcare institutions (PHIs) in China.
Haishaerjiang Wushouer, Kexin Du, Junxuan Yu, Wanmeng Zhang, Lin Hu, Weihsin Ko, Mengyuan Fu, Bo Zheng, Luwen Shi, Xiaodong Guan   +9 more
doaj   +1 more source