Results 71 to 80 of about 165,322 (267)

Appropriateness of maternal referral system and its associated factors in Eastern Ethiopia: a facility-based cross-sectional study

Frontiers in Global Women's Health
BackgroundGiven majority of obstetric complications are often unpredictable, an appropriate maternal referral system is crucial to manage life-threatening obstetric complications and prevent maternal deaths. Although Ethiopia is one of the countries with
Betelhem Mengist Sharew, Agumasie Semahegn, Agumasie Semahegn, Agumasie Semahegn, Shegaye Yibabie Damtie, Nigus Kassie Worku, Abera Kenay Tura, Abera Kenay Tura, Abera Kenay Tura   +8 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Outpatient Antibiotic Prescribing Patterns in Children among Primary Healthcare Institutions in China: A Nationwide Retrospective Study, 2017–2019

Antibiotics
There is scarce evidence to demonstrate the pattern of antibiotic use in children in China. We aimed to describe antibiotic prescribing practices among children in primary healthcare institutions (PHIs) in China.
Haishaerjiang Wushouer, Kexin Du, Junxuan Yu, Wanmeng Zhang, Lin Hu, Weihsin Ko, Mengyuan Fu, Bo Zheng, Luwen Shi, Xiaodong Guan   +9 more
doaj   +1 more source

Pragmatic competence and the CEFR: pragmatic profiling as a link between theory and language use

Linguistica, 2014
The functional and communicative perspective on language advocated in the Common European Framework of Reference for Languages (CEFR), hides the fact that, while the CEFR programmatically emphasises the role of pragmatic competence in language learning,
Pawel Sickinger, Klaus Peter Schneider
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Gamification in geography. Use, appropriateness and proposals according to university students in Spain

European Journal of Geography
Gamification awakens interest and motivation for teaching Geography. The objective of this study is to analyse the use, appropriateness and proposals according to university students in Spain.
Alvaro-Francisco Morote, María Hernández Hernández   +1 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Embracing transition to ethical digital advertising: Appropriateness of prosocial advergames from a parental perspective

Cogent Business & Management
Prosocial advergames are an innovative form of interactive advertising that communicates CSR efforts, aligns with societal values, and promotes sustainability with reference to the Triple-P concept.
Fatma Choura, Ali Ben Yahia, Sihem Ben Saad   +2 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source