Results 61 to 70 of about 165,322 (267)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Appropriateness of intended antibiotic prescribing using clinical case vignettes in primary care, and related factors

European Journal of General Practice
Background Factors associated with the appropriateness of antibiotic prescribing in primary care have been poorly explored. In particular, the impact of computerised decision-support systems (CDSS) remains unknown.Objectives We aim at investigating the ...
Tristan Delory, Alexis Maillard, Florence Tubach, Pierre-Yves Böelle, Elisabeth Bouvet, Sylvie Lariven, Pauline Jeanmougin, Josselin Le Bel   +7 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Improving lipid-lowering treatment and cardiovascular risk management in primary care: findings from an audit and feedback project

Frontiers in Pharmacology
IntroductionCardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Low-density lipoprotein cholesterol (LDL-C) plays a central role in atherogenesis and cardiovascular events.
Michelangelo Rottura, Selene Francesca Anna Drago, Antonino Molonia, Viviana Maria Gianguzzo, Federica Maria Sacco, Giovanni Pallio, Natasha Irrera, Riccardo Scoglio, Sebastiano Marino, Salvatore Corrao, Giuseppe Mandraffino, Egidio Imbalzano, Vincenzo Arcoraci   +12 more
doaj   +1 more source

EXOTIZACIÓN, DOMESTICACIÓN Y NIVELACIÓN EN LA TRADUCCIÓN DE OBRAS LITERARIAS Y DE TÍTULOS DE OBRAS DE ARTE PLÁSTICO [PDF]

Diversitate si Identitate Culturala in Europa, 2013
The theory of literary translation presupposes, apart from the norms that requi re a minimum semantic equivalence between the source language and the target language, a strategy of the translator's intervention in the text as well.
José Manuel POZO LÓPEZ
doaj  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

On the Requirements of Legal Justice of the Administrative Law Enforcement Activity

Сибирское юридическое обозрение, 2020
The article considers issues of understanding by the administrative-legal science of legal justice of the law-enforcement activity of executive authorities, other public administration bodies.
S. V. Yarkovoy
doaj  

Appropriateness of Brain Magnetic Resonance Imaging (MRI) Prescriptions and Imposed Financial Burden: Evidence from Iran

Journal of Evidence Based Health Policy, Management & Economics, 2022
Background: The use of advanced and expensive technologies requires financial, human and capital resources. Brain Magnetic Resonance Imaging (MRI) has high contrast sensitivity for visualizing differences among the tissues. Unnecessary diagnostic imaging
Mohammadreza Kalantarhormozi, Ahmad Yazdanpanah, Mohammadreza Yazdankhahfard, Batool Amiri, Reza Nemati, Milad Sohrabi Shekafti, Hedayat Salari, Atefe Esfandiari   +7 more
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source