Results 81 to 90 of about 14,953 (260)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Integrated Framework for Internal Replenishment Processes of Warehouses Using Approximate Dynamic Programming

Applied Sciences
Warehouses are vital in linking production to consumption, often using a forward–reserve layout to balance picking efficiency and bulk storage. However, replenishing the forward area from reserve storage is prone to delays and congestion, especially ...
İrem Kalafat, Mustafa Hekimoğlu, Ahmet Deniz Yücekaya, Gökhan Kirkil, Volkan Ş. Ediger, Şenda Yıldırım   +5 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A non-iterative distributed approximate dynamic programming algorithm for frequency security-constrained stochastic economic dispatch

International Journal of Electrical Power & Energy Systems
Due to uncertainties associated with the power output of offshore wind farms, the active power balance and frequency security control of power systems with lots of offshore wind farms are highly challenging.
Xiangyong Feng, Shunjiang Lin, Yutao Liang, Yanghua Liu, Mingbo Liu   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multistage reliability-constrained stochastic planning of diamond distribution network: An approximate dynamic programming approach

International Journal of Electrical Power & Energy Systems
In this paper, a multistage reliability-constrained stochastic planning model is established for the diamond distribution network, a new type of distribution system grid structure, with the goal of optimizing the total cost of investment and operation ...
Zhi Wu, Ao Li, Qirun Sun, Shu Zheng, Jingtao Zhao, Pengxiang Liu, Wei Gu   +6 more
doaj   +1 more source

Dynamic Programming for Approximate Expansion Algorithm [PDF]

, 2012
Expansion algorithm is a popular optimization method for labeling problems. For many common energies, each expansion step can be optimally solved with a min-cut/max flow algorithm. While the observed performance of max-flow for the expansion algorithm is fast, its theoretical time complexity is worse than linear in the number of pixels.
openaire   +2 more sources

DYNAMIC PROGRAMMING, SUCCESSIVE APPROXIMATIONS, AND MONOTONE CONVERGENCE [PDF]

Proceedings of the National Academy of Sciences, 1958
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources