Results 111 to 120 of about 3,285,936 (243)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Including Social Nash Equilibria in Abstract Economies [PDF]
We consider quasi-variational problems (variational problems having constraint sets depending on their own solutions) which appear in concrete economic models such as social and economic networks, financial derivative models, transportation network ...
Jacqueline Morgan, M. Beatrice Lignola
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Approximate social nash equilibria and applications [PDF]
In this paper, a concept of approximate social Nash equilibria is considered and an existence result is given when the strategic spaces of the players are not compact. These have been obtained using an approximate fixed point theorem.
Vincenzo Scalzo
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
The stochastic elementary formula method and approximate travelling waves for semi-linear reaction diffusion equations [PDF]
In this thesis we consider approximate travelling wave solutions for stochastic and generalised KPP equations and systems by using the stochastic elementary formula method of Elworthy and Truman.
Zhao, Huaizhong
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Singular Langmuir-Hinshelwood reaction-diffusion problems. strong absorption under quasi-isothermal conditions [PDF]
, 1982 The steady state reaction-diffusion problem is considered for a permeable catalytic particle with Langmuir-Hinshelwood kinetics under isothermal and quasi-isothermal conditions.
Vega de Prada, José Manuel +1 more
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An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
ε-solutions for quasi-variationalinequalities
, 2007 Approximate solutions for quasi-variational inequalities and for vector quasi-variationalinequalities have been recently investigated by the speaker.In this talk, we introduce and analyze the corresponding concepts of well-posedness and discuss about the
LIGNOLA, MARIA BEATRICE
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