Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On the Convergence of Numerical Computations for Both Exact and Approximate Solutions for Electromagnetic Scattering by Nonspherical Dielectric Particles. [PDF]
Electromagn Waves (Camb), 2019 Yang P +5 more
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Erratum: Brain-mechanistic responses to varying difficulty levels of approximate solutions to arithmetic problems. [PDF]
Sci Rep, 2016 Xiang Y, Jiang Y, Chao X, Wu Q, Mo L.
europepmc +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Approximate solutions of the generalized Gołąb-Schinzel equation
Journal of Inequalities and Applications, 2006 Motivated by the problem of R. Ger, we show that the generalized Gołąb-Schinzel equation is superstable in the class of functions hemicontinuous at the origin. As a consequence, we obtain the form of approximate solutions of that equation.
Chudziak Jacek
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Logical gaps in the approximate solutions of the social learning game and an exact solution. [PDF]
PLoS One, 2014 Dai W, Wang X, Di Z, Wu J.
europepmc +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Brain-mechanistic responses to varying difficulty levels of approximate solutions to arithmetic problems. [PDF]
Sci Rep, 2016 Xiang Y, Jiang Y, Chao X, Wu Q, Mo L.
europepmc +1 more source