Results 91 to 100 of about 5,627 (286)

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Faster Approximate Elastic-Degenerate String Matching - Part B [PDF]

We revisit the complexity of approximate pattern matching in an elastic-degenerate string. Such a string is a sequence of n finite sets of strings of total length N, and compactly describes a collection of strings obtained by first choosing exactly one ...
Pissis, Solon P., Pokorski, K. (Karol), Górkiewicz, A. (Adam), Marciniak, P. (Pola), Gawrychowski, Paweł, Pissis, Solon P.; id_orcid, Pissis, S. (Solon), Marciniak, Pola, Gawrychowski, P. (Paweł), Pokorski, Karol, Górkiewicz, Adam   +10 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

A polynomial time biclustering algorithm for finding approximate expression patterns in gene expression time series

Algorithms for Molecular Biology, 2009
Background The ability to monitor the change in expression patterns over time, and to observe the emergence of coherent temporal responses using gene expression time series, obtained from microarray experiments, is critical to advance our understanding ...
Madeira Sara C, Oliveira Arlindo L
doaj   +1 more source

A Preprocessing for Approximate String Matching

, 2011
Approximate string matching is a basic and important concept in many applications of information retrieval. This paper proposes an algorithm for the problem of approximate string matching.
馬場, 謙介, Ikeda, Daisuke, 中藤, 哲也, Nakatoh, Tetsuya, 池田, 大輔, Yamada, Yasuhiro, Baba, Kensuke   +6 more
core  

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

De novo identification of LTR retrotransposons in eukaryotic genomes

BMC Genomics, 2007
Background LTR retrotransposons are a class of mobile genetic elements containing two similar long terminal repeats (LTRs). Currently, LTR retrotransposons are annotated in eukaryotic genomes mainly through the conventional homology searching approach ...
Kim Sun, Choi Jeong-Hyeon, Rho Mina, Lynch Michael, Tang Haixu   +4 more
doaj   +1 more source

Generative AI‐Driven Accelerated Discovery of Passivation Molecules for Perovskite Solar Cells

Advanced Science, EarlyView.
A generative artificial intelligence (AI) framework combining a discriminative machine learning model (SMILES‐X) and a generative language model (GPT‐2) autonomously discovers new molecular passivators for perovskite solar cells (PSCs). Through an iterative design loop, over 100 000 candidates are generated and screened, and randomly selected molecules
Adroit T. N. Fajar, Guillaume Lambard, Jessie Manopo, Ruili Guo, Kevin Septioga, Rizfi F. Pari, Toshinori Matsushima, Zhanglin Guo   +7 more
wiley   +1 more source

3-Partition Order-Preserving Pattern Matching

Mathematics
Two strings of equal length are called order-isomorphic if their relative orders are identical at every position. The classical order-preserving pattern matching (OPPM) problem finds all substrings in a text T that are order-isomorphic to a pattern P ...
Joong Chae Na, Seokchul Kang, Jeong Seop Sim   +2 more
doaj   +1 more source

Indexed Hierarchical Approximate String Matching [PDF]

, 2008
We present a new search procedure for approximate string matching over suffix trees. We show that hierarchical verification, which is a well-established technique for on-line searching, can also be used with an indexed approach. For this, we need that the index supports bidirectionality, meaning that the search for a pattern can be updated by adding a ...
Luís M. S. Russo, Gonzalo Navarro 0001, Arlindo L. Oliveira   +2 more
openaire   +1 more source