Results 91 to 100 of about 1,875,358 (236)
Global Sampling for Sequential Filtering over Discrete State Space
EURASIP Journal on Advances in Signal Processing, 2004 In many situations, there is a need to approximate a sequence of probability measures over a growing product of finite spaces. Whereas it is in general possible to determine analytic expressions for these probability measures, the number of computations
Cheung-Mon-Chan Pascal, Moulines Eric
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International Journal of Differential Equations, 2009 An analytical expression for the solution of the prey-predator problem by an adaptation of the homotopy analysis method (HAM) is presented. The HAM is treated as an algorithm for approximating the solution of the problem in a sequence of time intervals ...
A. K. Alomari +2 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
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Theoretical limit of link prediction using a combination method
Tongxin xuebao, 2020 The problem that whether there a theoretical limit exists for link prediction combination methods and how to approximate was investigated.Link prediction methods were divided into single or combination methods,based on whether multidimension information ...
Yiteng WU +3 more
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Approximating a sequence of observations by a simple process [PDF]
Given a sequence (s0; s1,..., sN) of observations from a finite set S, we construct a process (sn)n_Markov chains; approximation ...
ROSENBERG, Dinah +2 more
core
APPROXIMATING NASH EQUILIBRIA IN NONZERO-SUM GAMES
, 2011 This paper deals with the approximation of Nash equilibria in m-player games. We present conditions under which an approximating sequence of games admits nearequilibria that approximate near-equilibria in the limit game.
ALTMAN, EITAN +3 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Sequence Comparison Significance and Poisson Approximation
Statistical Science, 1994 The Chen-Stein method of Poisson approximation has been used to establish theorems about comparison of two DNA or protein sequences. The most useful result for sequence alignment applies to alignment scoring with no gaps. However, there has not been a valid method to assign statistical significance to alignment scores with gaps. In this paper we extend
Waterman, Michael S., Vingron, Martin
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
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